Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
about
Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cellsSkp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- miceRetinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategiesTwists in views on RB functions in cellular signaling, metabolism and stem cellsThe role of Cdk5 in neuroendocrine thyroid cancerPerturbation biology: inferring signaling networks in cellular systemsMicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-rasThe retinoblastoma tumor-suppressor gene, the exception that proves the ruleRetinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis.p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior.Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegansA network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Wild-type NRas and KRas perform distinct functions during transformation.ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.Emerging roles of RB family: new defense mechanisms against tumor progression.Antitumor mechanisms when pRb and p53 are genetically inactivated.A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis.The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
P2860
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P2860
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
description
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
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im Dezember 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/12/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/12/01)
@nl
наукова стаття, опублікована в грудні 2004
@uk
مقالة علمية (نشرت في ديسمبر 2004)
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name
Genetic interaction between Rb ...... ntiation and tumor suppression
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Genetic interaction between Rb ...... ntiation and tumor suppression
@en
Genetic interaction between Rb ...... ntiation and tumor suppression
@nl
type
label
Genetic interaction between Rb ...... ntiation and tumor suppression
@ast
Genetic interaction between Rb ...... ntiation and tumor suppression
@en
Genetic interaction between Rb ...... ntiation and tumor suppression
@nl
prefLabel
Genetic interaction between Rb ...... ntiation and tumor suppression
@ast
Genetic interaction between Rb ...... ntiation and tumor suppression
@en
Genetic interaction between Rb ...... ntiation and tumor suppression
@nl
P2093
P2860
P1476
Genetic interaction between Rb ...... ntiation and tumor suppression
@en
P2093
Bernardo Contreras
Chiaki Takahashi
Mark E. Ewen
Massimo Loda
Roderick T. Bronson
P2860
P304
10406–10415
P356
10.1128/MCB.24.23.10406-10415.2004
P407
P577
2004-12-01T00:00:00Z