Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
about
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphologyThe epigenetic landscape of addictionEarly life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signalingThe role of ventral striatal cAMP signaling in stress-induced behaviors.Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.Mechanisms of psychostimulant-induced structural plasticityLocomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbensStriatal signal transduction and drug addictionTargeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked BehaviorCdk5 phosphorylates dopamine D2 receptor and attenuates downstream signalingKalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and functionAttention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell.Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.Kalrn promoter usage and isoform expression respond to chronic cocaine exposureThe addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.Behavioral and morphological responses to cocaine require kalirin7.Epigenetics, microRNA, and addiction.Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioningProtein kinases and addiction.Cocaine regulates MEF2 to control synaptic and behavioral plasticityNicotine decreases food intake through activation of POMC neurons.Regulation of Neuronal Function by Ras-GRF Exchange Factors.Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisineAberrant learning and memory in addiction.Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues.Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety.Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.Appetitive changes during salt deprivation are paralleled by widespread neuronal adaptations in nucleus accumbens, lateral hypothalamus, and central amygdala.Epigenetics of drug abuse: predisposition or response.Glutathione-s-transferases as determinants of cell survival and death.State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing.Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.Cdk5 is essential for adult hippocampal neurogenesisBiological substrates of reward and aversion: a nucleus accumbens activity hypothesis.Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral StriatumMaking a neuron: Cdk5 in embryonic and adult neurogenesis.Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.
P2860
Q23912227-BC9AD2B4-2309-4AA3-B311-24B4D1A1EEA2Q24624411-F626DE22-9DF8-4CF7-986A-49779951A869Q24655015-B6AC258F-9E91-4995-851F-5F58122C63A9Q27312156-6F897324-D70F-4304-9B1F-2ED19FBDDC4AQ28389040-7FB74276-1CCD-4957-BF76-00CD92FDEA59Q28389221-33EA247D-BDE1-4CFC-B8F5-2573D0A19F3CQ28389962-3D5B1A70-CB2E-4F57-9A57-2AAFEDD62CD3Q28390747-5B647848-8219-4B83-843D-211B67F80066Q28392093-D1675807-2E34-4497-BA03-E6A9A8AA3B71Q28393129-7FFFE479-A3B6-4912-98A8-55B39D1261C7Q28393537-9F8ED983-DDE6-4444-856D-9965799F4ED7Q28509168-69F20BD6-7C5F-4BD4-B09F-94B2534F90F9Q28585726-2E711B95-1F61-42AE-864D-897D4446F836Q30511735-DB9C63E0-EF52-47DA-97CA-08A70F59FB47Q33556356-66D0BB4A-F96E-483D-8941-D4C8E57A2878Q33823125-ACDF348C-BA34-425C-AF90-AF520AE41F01Q33940362-099D6C68-601F-47CD-A387-A4EA8C976DC7Q34009298-6F8AFDFA-7953-4EFF-833F-686DAAF3506AQ34426201-67994B5A-8AE4-4CF1-894E-478A745BA23CQ34618617-864B7E74-3C3B-49C8-AF74-E573D705D7AFQ34630295-F36712B1-16CD-47D6-A419-293E6AD06741Q34818266-390831A7-6516-43C3-AF96-92A46354E3A6Q35041265-4767FB09-D6BB-4132-9F75-FFED417842ABQ35083736-A3FA74B0-B1B5-4A24-9648-C87951E7B382Q35089398-CF0E2FA1-B6C7-4E94-B9D6-A47C70B18998Q35112659-AB89FFD0-4047-48CF-AFEC-2E24A064468DQ35147281-94903260-C54B-45F2-A664-2FF6068B510FQ35898416-4A786497-5BEE-4978-85C0-01572C2E9966Q36029486-36FCD469-F58F-4A1D-BB02-0B38FD8D39ACQ36178796-54FB76A1-309E-4B2D-BEC8-54CF11AE1E46Q36295032-B804DF94-2BF3-4325-8BEB-66C8586C0F2CQ36326547-F24414F6-C40B-4F75-B0E5-428B8AD8C99AQ36709870-C47283D3-E27E-4C93-A16B-BF5E43C13179Q36940161-E21CA59F-E99D-42D7-ACD6-86895209B465Q36985126-0D1FD840-F329-4706-AF13-059348D0737AQ37082551-9F4033CE-1466-4888-B7B4-C6D7285E2E03Q37117817-579EA18F-8B63-4987-A49D-9C95429DBAAEQ37399885-052191DB-3FA8-4C59-9CD3-97FA1EA61D9FQ37402773-8C05870F-B0EA-462F-B272-B3254A9D6822Q37415588-5C8EF7DD-0B33-4990-B0A0-0B82439FE884
P2860
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
description
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im November 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/11/21)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/11/21)
@nl
наукова стаття, опублікована в листопаді 2007
@uk
مقالة علمية (نشرت في 21-11-2007)
@ar
name
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@ast
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@en
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@nl
type
label
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@ast
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@en
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@nl
prefLabel
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@ast
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@en
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@nl
P2093
P921
P3181
P1476
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
@en
P2093
Ammar H Hawasli
David R Benavides
James A Bibb
Jane R Taylor
Janice W Kansy
Jennifer J Quinn
Peter Olausson
Ping Zhong
P304
12967-12976
P3181
P356
10.1523/JNEUROSCI.4061-07.2007
P407
P577
2007-11-21T00:00:00Z