ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
about
Epidermal development in mammals: key regulators, signals from beneath, and stem cellsA step closer toward therapies for p63-related disordersAPR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutationsΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiationSorting of Sox1-GFP Mouse Embryonic Stem Cells Enhances Neuronal Identity Acquisition upon Factor-Free Monolayer Differentiation.p53/p63/p73 in the epidermis in health and diseaseTAp63 is important for cardiac differentiation of embryonic stem cells and heart development.Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene.A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells.P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.Regulation of skin aging and heart development by TAp63.Disruption of eyelid and cornea morphogenesis by epithelial β-catenin gain-of-function.Genetic and cellular mechanisms regulating anterior foregut and esophageal development.ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion.Role of p63 in Development, Tumorigenesis and Cancer ProgressionTissue-specific expression of p73 C-terminal isoforms in mice.p63 the guardian of human reproduction.Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.Caspase-1 is a novel target of p63 in tumor suppression.Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinomaNotch signaling represses p63 expression in the developing surface ectoderm.Cutaneous Notch signaling in health and disease.Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification.p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells.GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma.ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis.Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.A symphony of regulations centered on p63 to control development of ectoderm-derived structures.Role of the promyelocytic leukaemia protein in cell death regulation.Senescence regulation by the p53 protein familyA new hope: novel therapeutic approaches to treatment of chronic lymphocytic leukaemia with defects in TP53.MicroRNAs and p63 in epithelial stemness.Alterations of p63 and p73 in human cancers.Epidermal cell junctions and their regulation by p63 in health and disease.
P2860
Q26823139-43B51144-3A4C-4A53-97DF-3BF1F9559728Q28243496-B1A494C5-9BDF-4C2D-AF98-464F39FEB807Q28284341-CB5B2DD1-1210-4D8C-A8F5-FFB29C8CEB1FQ28587251-0CDED979-D8F7-46FA-954B-7C714A966278Q33724520-8CCE02E8-4BB5-49D0-A91B-803EF78A2346Q33944382-774CBFFB-4EA8-4B9B-B5C1-5B980BD9FBFCQ34214162-77EA663D-9477-4F77-AC06-A2ACDC5F6231Q34396280-7408634E-9305-4E36-BE87-4F892D52AF66Q34635626-C17FC3E2-4F76-490F-AE25-20C58F2B57E2Q34828404-57D375F7-EFC5-4BC2-9365-6AE2417FA854Q35098103-CBDCCB15-9BAC-4782-B57C-0A59168ED283Q35227440-A96914FD-229F-46C7-98E6-769FB109B7B9Q35546335-3391BDA9-F8FB-46F8-9FE6-0D78DD095B93Q35687106-3DFD08EE-B856-47A2-9910-D08E31566F7DQ35908630-8973DC94-EDAE-46F5-8D39-4E911F348843Q36131001-D01DB968-27B2-4AD7-BA6D-885C01990971Q36179548-C0CB3A16-08B0-4B60-8EDD-0DD66F1EEB3AQ36284945-3A6E0D97-4B28-4A0C-8AB8-5D034FBE316EQ36556362-15CA3ACD-86A6-41A3-9D79-B526DC9B8CEAQ36581663-A2616348-E00A-4630-B4C1-9F527C8730D9Q36598086-26455C8B-613B-441F-B585-649854F48D31Q36907168-48B86D48-2091-4994-86AD-0CC62DF8C7D3Q37030292-0FCE3E74-FA91-4C37-8E44-9FD29F22A3FEQ37052955-9D0D84ED-A9FC-41D7-821D-6EFA368F2C75Q37124587-3850D697-67B0-4867-BB51-06FF76C97197Q37340356-8E91FBB8-A711-4794-9ED7-4F134B1D49F0Q37363383-68083852-722F-48AC-BCE4-F8F20E392FB1Q37398481-960E1F21-3027-4D8B-9D8E-A2336161E4D9Q37530290-28F6B124-9421-4C92-A7DF-8AEEF8E2D79FQ37571123-B1087D3C-4ED0-4152-924A-3AB3CF227EADQ37594182-4004946B-E2D2-4354-9685-D1B85BA5676BQ37656142-6C608959-ABE3-4111-A659-01ADC7F5A0B3Q37689011-4762B772-861A-4149-8A23-2B7E5AE05B85Q37895920-A0EB0B9B-EAC5-40C7-8D72-B86F77C30FEFQ37975087-4C5BED4A-AFE4-415E-BB36-2BE215AF6FF6Q38072351-0319867A-61CA-4822-BBE8-4240A2276DA1Q38231432-9E388BFD-80D6-4AFF-820F-E96B2DCF7452Q38244285-C408DD72-0C75-490A-B667-8D3B8573D160Q38247152-9217E91D-8528-4C03-A669-2432418B2865Q38341838-9F8EC364-1B4C-42C8-8395-0B477DA87EC1
P2860
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
description
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Mai 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/05/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/05/01)
@nl
наукова стаття, опублікована в травні 2011
@uk
مقالة علمية (نشرت في مايو 2011)
@ar
name
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@ast
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@en
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@nl
type
label
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@ast
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@en
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@nl
prefLabel
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@ast
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@en
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@nl
P2093
P2860
P3181
P356
P1476
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
@en
P2093
A. M. Lena
D. Aberdam
H. Van Bokhoven
R. Shalom-Feuerstein
S. De La Forest Divonne
P2860
P2888
P304
P3181
P356
10.1038/CDD.2010.159
P577
2011-05-01T00:00:00Z