Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
about
Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationHIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activityThe phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repressionl7Rn6 encodes a novel protein required for clara cell function in mouse lung developmentHypoxic regulation of erythropoiesis and iron metabolismGrowth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetryAberrant Pulmonary Vascular Growth and Remodeling in Bronchopulmonary DysplasiaPathogenesis of bronchopulmonary dysplasia: when inflammation meets organ developmentEpithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumorsCul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implicationsHypoxic signaling during tissue repair and regenerative medicineHIF hydroxylase pathways in cardiovascular physiology and medicinePulmonary effects of prolonged oligohydramnios following mid-trimester rupture of the membranes--antenatal and postnatal managementHypoxia-inducible factors in physiology and medicineOn safety, pharmacokinetics and dosage of bevacizumab in ROP treatment - a reviewHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionLoss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In MiceRole of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice LungsIron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiencyHypoxia-inducible factors in the kidneyNovel insights into the molecular origins and treatment of lung cancerLymphatic function is required prenatally for lung inflation at birth.VEGF links hippocampal activity with neurogenesis, learning and memoryHypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryosAcute postnatal ablation of Hif-2alpha results in anemiaHypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivoDifferential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulationUp-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 inductionIntegrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification.Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.Efficient derivation of alveolar type II cells from embryonic stem cells for in vivo application.Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation.Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.A systems approach to mapping transcriptional networks controlling surfactant homeostasis.
P2860
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P2860
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
description
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Juli 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/07/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/07/01)
@nl
наукова стаття, опублікована в липні 2002
@uk
مقالة علمية (نشرت في يوليو 2002)
@ar
name
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@ast
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@en
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@nl
type
label
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@ast
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@en
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@nl
prefLabel
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@ast
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@en
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@nl
P2093
P50
P921
P1433
P1476
Loss of HIF-2alpha and inhibit ...... ory distress in premature mice
@en
P2093
Benoit Nemery
Désiré Collen
Eli Keshet
Florea Lupu
Heike Beck
Karl Plate
Koen Brusselmans
Lieve Moons
Paul Van Veldhoven
P2888
P304
P356
10.1038/NM1102-1329B
10.1038/NM721
P407
P577
2002-07-01T00:00:00Z