Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
about
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determinationBASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiationMale sex determination: insights into molecular mechanismsMTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factorNew clues to the puzzle of mammalian sex determinationFinding signals that regulate alternative splicing in the post-genomic eraZebrafish sex determination and differentiation: involvement of FTZ-F1 genesCell fate commitment during mammalian sex determinationAcute multiple organ failure in adult mice deleted for the developmental regulator Wt1Mammalian sex determination—insights from humans and mice.The many facets of the Wilms' tumour gene, WT1Genetic control of testis developmentAnalyzing the coordinated gene network underlying temperature-dependent sex determination in reptilesCoronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1.Follistatin operates downstream of Wnt4 in mammalian ovary organogenesisThe Wilms' tumor gene Wt1 is required for normal development of the retinaNovel markers of early ovarian pre-granulosa cells are expressed in an Sry-like patternA naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit.The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAsLoss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors.Inducible nephrin transgene expression in podocytes rescues nephrin-deficient mice from perinatal deathTransgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal glandSwitching on sex: transcriptional regulation of the testis-determining gene SryEstablishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.Colocalization of WT1 and cell proliferation reveals conserved mechanisms in temperature-dependent sex determination.Hatching enzymes disrupt aberrant gonadal degeneration by the autophagy/apoptosis cell fate decisionAlternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms.A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathwayIn mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures.The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.Tumors of bilateral streak gonads in patients with disorders of sex development containing y chromosome material.Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform.Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.
P2860
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P2860
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/08/10)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/10)
@nl
наукова стаття, опублікована в серпні 2001
@uk
مقالة علمية (نشرت في 10-8-2001)
@ar
name
Two splice variants of the Wil ...... mination and nephron formation
@ast
Two splice variants of the Wil ...... mination and nephron formation
@en
Two splice variants of the Wil ...... mination and nephron formation
@nl
type
label
Two splice variants of the Wil ...... mination and nephron formation
@ast
Two splice variants of the Wil ...... mination and nephron formation
@en
Two splice variants of the Wil ...... mination and nephron formation
@nl
prefLabel
Two splice variants of the Wil ...... mination and nephron formation
@ast
Two splice variants of the Wil ...... mination and nephron formation
@en
Two splice variants of the Wil ...... mination and nephron formation
@nl
P2093
P3181
P1433
P1476
Two splice variants of the Wil ...... mination and nephron formation
@en
P2093
D. Landrock
J. R. Leheste
M. C. Gubler
U. Ziegler
P304
P3181
P356
10.1016/S0092-8674(01)00453-6
P407
P577
2001-08-10T00:00:00Z