Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin
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Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assayCell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21qTemperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataractMethionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stressActivation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lensesMorphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lensGeneration of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary oDifferentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent ReporterTXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lensConcurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallinThe molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stressInteractions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lensSox1 directly regulates the gamma-crystallin genes and is essential for lens development in miceExacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxiaMechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell deathalpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stressFunctions of crystallins in and out of lens: roles in elongated and post-mitotic cellsMitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerationsMass spectrometry quantifies protein interactions--from molecular chaperones to membrane porins.Identification of Sequence Similarities among Isomerization Hotspots in Crystallin Proteins.The eye lens chaperone alpha-crystallin forms defined globular assemblies.Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis.Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivatesAlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.The eye lens cytoskeleton.Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.Characterization of alpha-crystallin-plasma membrane bindingStructural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts.Small heat shock proteins, the cytoskeleton, and inclusion body formation.Adaptive evolution of small heat shock protein/alpha B-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi.Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression.Mutations in human αA-crystallin/sHSP affect subunit exchange interaction with αB-crystallin.Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis.αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling.Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone.Small heat-shock proteins protect from heat-stroke-associated neurodegeneration.Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells
P2860
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P2860
Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin
description
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1997
@ast
im Februar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/02/04)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/02/04)
@nl
наукова стаття, опублікована в лютому 1997
@uk
name
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@ast
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@en
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@nl
type
label
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@ast
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@en
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@nl
prefLabel
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@ast
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@en
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@nl
P2093
P2860
P3181
P356
P1476
Targeted disruption of the mou ...... ock protein alpha B-crystallin
@en
P2093
D. Garland
E. F. Wawrousek
J. P. Brady
W. G. Robison
Y. Duglas-Tabor
P2860
P304
P3181
P356
10.1073/PNAS.94.3.884
P407
P577
1997-02-04T00:00:00Z