Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
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Fundamentals of cancer metabolismUnexploited Antineoplastic Effects of Commercially Available Anti-Diabetic DrugsMedium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer CellsCombined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatinActivation of AMPKα mediates additive effects of solamargine and metformin on suppressing MUC1 expression in castration-resistant prostate cancer cellsGermline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis.Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.Pharmacological Management of Gestational Diabetes Mellitus.Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems.An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.Combinational strategies of metformin and chemotherapy in cancers.Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification.One-Carbon Metabolism in Health and Disease.A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.MYC and AMPK-Save Energy or Die!Regulation of organelle function by metformin.The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration.Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells.Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.Metformin inhibits SUV39H1-mediated migration of prostate cancer cells.Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.Cancer: Linking Powerhouses to Suicidal Bags.Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.Metformin targets histone acetylation in cancer-prone epithelial cells.Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes.Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity.Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention.Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study.Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.Fatty acid synthase (FASN) as a therapeutic target in breast cancer.Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction.Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis.Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells.
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P2860
Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
description
2015 nî lūn-bûn
@nan
2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@ast
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@en
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@nl
type
label
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@ast
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@en
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@nl
prefLabel
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@ast
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@en
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@nl
P2093
P2860
P50
P3181
P1433
P1476
Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis
@en
P2093
Jocelyn Chen
Ralph J DeBerardinis
Robert Egnatchik
Russell G Jones
Takla Griss
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1002309
P407
P577
2015-12-01T00:00:00Z