Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
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Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cellsPrecursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingHuntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsActivation of the Sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astrogliaThe pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with AβStudies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory DysfunctionProBDNF collapses neurite outgrowth of primary neurons by activating RhoA.Mesenchymal stem cells for the treatment of neurodegenerative disease.Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation.Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy.Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice.Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy.Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans.MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models.Huntington's disease, calcium, and mitochondria.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders.Primary cilia and autophagic dysfunction in Huntington's disease.HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.Mesenchymal stem cells for trinucleotide repeat disordersEndogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice.HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.Roles of BDNF in spinal neuroplasticity in cats subjected to partial dorsal ganglionectomy.The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
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Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
description
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2010
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im Februar 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2010/02/19)
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vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/02/19)
@nl
наукова стаття, опублікована в лютому 2010
@uk
name
Huntingtin-associated protein- ...... ates its transport and release
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Huntingtin-associated protein- ...... ates its transport and release
@en
Huntingtin-associated protein- ...... ates its transport and release
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type
label
Huntingtin-associated protein- ...... ates its transport and release
@ast
Huntingtin-associated protein- ...... ates its transport and release
@en
Huntingtin-associated protein- ...... ates its transport and release
@nl
prefLabel
Huntingtin-associated protein- ...... ates its transport and release
@ast
Huntingtin-associated protein- ...... ates its transport and release
@en
Huntingtin-associated protein- ...... ates its transport and release
@nl
P2093
P2860
P356
P1476
Huntingtin-associated protein- ...... ates its transport and release
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P2093
Linda Lin-yan Wu
Xiao-Jiang Li
Yongjun Fan
P2860
P304
P356
10.1074/JBC.M109.073197
P407
P50
P577
2010-02-19T00:00:00Z