Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
about
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppressionActivity-regulated genes as mediators of neural circuit plasticityAltered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures.REST and CoREST modulate neuronal subtype specification, maturation and maintenance.The function of activity-regulated genes in the nervous system.The ubiquitin-proteasome pathway and synaptic plasticity.Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.Ubiquitination in postsynaptic function and plasticityPLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferationFrom Plk1 to Plk5: functional evolution of polo-like kinasesMice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioningUnderstanding cullin-RING E3 biology through proteomics-based substrate identificationCYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent mannerPrion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome systemUbiquitination of neurotransmitter receptors and postsynaptic scaffolding proteinsSpatial organization of ubiquitin ligase pathways orchestrates neuronal connectivity.Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptationThink locally: control of ubiquitin-dependent protein degradation in neuronsAlternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticityUbiquitination: Added complexity in Ras and Rho family GTPase function.Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.Combinatorial morphogenesis of dendritic spines and filopodia by SPAR and alpha-actinin2.A systems-wide screen identifies substrates of the SCF TrCP ubiquitin ligaseAPCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
P2860
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P2860
Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
description
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im Oktober 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/10/24)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/10/24)
@nl
наукова стаття, опублікована в жовтні 2008
@uk
name
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@ast
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@en
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@nl
type
label
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@ast
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@en
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@nl
prefLabel
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@ast
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@en
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@nl
P2093
P2860
P356
P1476
Regulation of postsynaptic Rap ...... ligase in hippocampal neurons
@en
P2093
Daniel P. Seeburg
J. Wade Harper
Xiaolu L. Ang
P2860
P304
29424–29432
P356
10.1074/JBC.M802475200
P407
P50
P577
2008-10-24T00:00:00Z