The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans
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CCN3 (NOV) is a novel angiogenic regulator of the CCN protein familyFas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivoCYR61 (CCN1) is essential for placental development and vascular integrityExtracellular matrix associated protein CYR61 is linked to prostate cancer developmentMatricellular protein CCN1 activates a proinflammatory genetic program in murine macrophagesFunctions and mechanisms of action of CCN matricellular proteinsInvolvement of Cyr61 in growth, migration, and metastasis of prostate cancer cellsThe matrix protein CCN1 (CYR61) induces apoptosis in fibroblastsDifferential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation.A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesisEyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilaritiesTaking aim at the extracellular matrix: CCN proteins as emerging therapeutic targetsIdentification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells.Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) geneThe FOX transcription factors regulate vascular pathology, diabetes and TregsCCN1/CYR61: the very model of a modern matricellular protein.Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability.Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway.CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft.The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migrationBMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.Developmental and injury-induced expression of alpha1beta1 and alpha6beta1 integrins in the rat spinal cord.Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration.Mast Cell Proteases 6 and 7 Stimulate Angiogenesis by Inducing Endothelial Cells to Release Angiogenic Factors.Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma.Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer.DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain.Implication for transglutaminase 2-mediated activation of β-catenin signaling in neointimal vascular smooth muscle cells in chronic cardiac allograft rejectionUpregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain.Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.Matricellular protein CCN3 mitigates abdominal aortic aneurysm.Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesisForkhead transcription factors and cardiovascular biologyG protein-coupled receptors go extracellular: RhoA integrates the integrins.Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells.Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells.
P2860
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P2860
The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans
description
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
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im April 2002 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2002/04/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/04/01)
@nl
наукова стаття, опублікована у квітні 2002
@uk
مقالة علمية (نشرت في أبريل 2002)
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name
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@ast
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@en
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@nl
type
label
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@ast
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@en
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@nl
prefLabel
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@ast
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@en
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@nl
P2093
P3181
P1433
P1476
The angiogenic factor cysteine ...... heparan sulfate proteoglycans
@en
P2093
Lester F. Lau
Ningyu Chen
Stephen C.-T. Lam
Tatiana M. Grzeszkiewicz
Volkhard Lindner
P304
P3181
P356
10.1210/EN.143.4.1441
10.1210/ENDO.143.4.8731
P407
P577
2002-04-01T00:00:00Z