Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
about
Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transportFunctional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibitBiology of the major facilitative folate transporters SLC19A1 and SLC46A1The iron transporter ferroportin can also function as a manganese exporterZip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cellsNeoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound ironStructural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.Interaction of calcium with the human divalent metal-ion transporter-1.Folding and assembly of TMD 6-related segments of DMT 1 in trifluoroethanol aqueous solution.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionTargeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.Transmembrane topology of the mammalian Slc11a2 iron transporterIron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy.Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in miceDictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux.Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganeseLiver iron transportSubstrate profile and metal-ion selectivity of human divalent metal-ion transporter-1.Mathematical Modeling of Intestinal Iron Absorption Using Genetic Programming.ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loadingFate of blood meal iron in mosquitoesRecent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters.Iron and diabetes riskSmall-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro.The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.Iron: the hard player in diabetes pathophysiology.Oxygen in the regulation of intestinal epithelial transport.Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity.Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.Iron overload of human colon adenocarcinoma cells studied by synchrotron-based X-ray techniques.Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1.
P2860
Q24304315-11700339-6D12-4FA7-B2B1-4D7460AA24DBQ24305990-C8F0FDBF-51EE-4672-AEB9-BB82146BADC0Q24316057-8943FB86-D3ED-41B3-A22A-7FDE99662B12Q24631090-D362E44B-5507-46A8-8AFE-440658A0EFE6Q26998717-73A9FF41-A533-4F72-817A-CE71FCF0CE5FQ28255643-4C1264B0-C5FA-4044-B537-DC4990D17683Q28509880-D76B39EC-26CE-4DAA-A625-04112E456B69Q28570714-6AAC1CBF-49DB-415E-B133-7F6130F07C80Q30834787-C2748BEA-850C-4C24-BFF3-E0ABA040ECAFQ33616799-0207F910-73DD-4BBA-A4D7-1D00F668EEECQ33729284-20D20ADB-74BA-43BB-9C30-6B0B2AF4C118Q33933329-6197514A-07D1-4DEF-9AA1-8E6B46894433Q34129760-BAC33348-1C34-4FF6-B95C-9DD2937C0C46Q34310128-7A290D84-D0B6-45AF-9DD3-0C1E64A1D88BQ34658009-17828960-8AA8-4581-B800-BEE05D5E9D82Q34993234-3176BBF0-F78E-4689-B821-F748DA906BDFQ35032747-B84DC169-5B50-4C29-872D-AF1B872BFB73Q35322005-19653D08-A08E-417F-8A17-EF6E10C93E4FQ36067702-BCBC1186-6AB2-4DC9-BD7F-8049E1947572Q36091121-A6DA37C0-28DC-40D6-8918-1691300D4997Q36174536-AAEE8CEF-274D-4F8A-9E54-BEE81F7C1D02Q36177913-265E1814-2BA0-49AF-B9C4-EAE32ABF8756Q36216669-FC4C0569-F35A-4158-96CD-5E6DD8D95725Q36245615-B134F242-86B7-4961-B2F4-E93CA4644F53Q36298311-B8A14ECE-7C26-4064-A806-2C5756DC73D8Q36579059-0DD20963-C6DD-45BC-891C-3810BBBD046CQ36704535-BC8F0627-6B9D-4F69-99DA-248A1969EB2BQ36827829-DB598418-65B5-48D2-AEF5-FA295F45B062Q36890133-8328682D-D092-428C-8DF8-3B8611C6DE3CQ36985218-A23BF3EF-54D4-49E0-81A8-0C07D52C820EQ37264121-8D95C3DA-121C-44D0-8D65-0A11E651C59EQ37267127-87A0A23C-0867-4DA0-B968-3157F8C500B0Q37285318-3D1576C5-A805-4374-84C5-3067FCF18C20Q38187484-DBF00A6C-6ECC-4B97-8D09-F7F070AE5A08Q38202849-969913BA-F082-442C-92C4-5E46EC46F5D5Q38612279-0E4EAF60-AFBF-4990-9382-104E7E0ECA6DQ38646046-283A6817-8BFD-4F3B-8328-8DFCE55244FAQ38804270-2965F418-0AA8-4DFF-A46B-022AD4BC8E6CQ39622458-4D16F2F0-D68B-4C80-ACB3-E8024DA80754Q39849726-CE787597-69C3-416C-8521-70168D07F60F
P2860
Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
description
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Januar 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/01/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/01/01)
@nl
наукова стаття, опублікована в січні 2006
@uk
مقالة علمية (نشرت عام 2006)
@ar
name
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@ast
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@en
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@nl
type
label
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@ast
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@en
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@nl
prefLabel
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@ast
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@en
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@nl
P2093
P3181
P1433
P1476
Divalent metal-ion transporter ...... transport and uncoupled fluxes
@en
P2093
Bryan Mackenzie
M. L. Ujwal
Matthias A. Hediger
Michael F. Romero
Min-Hwang Chang
P2888
P304
P3181
P356
10.1007/S00424-005-1494-3
P577
2006-01-01T00:00:00Z
P6179
1032868878