INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
about
Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primatesEvolution of the relaxin-like peptide familySub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complexBursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distensionRelaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathwaysCumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicityStructure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 AgonistH3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexityINSL5 is a high affinity specific agonist for GPCR142 (GPR100)Paracrine regulation of mammalian oocyte maturation and male germ cell survivalCharacterization of the rat INSL3 receptorDetection, localization, and action of the INSL3 receptor, LGR8, in rat kidneyImpaired nipple development and parturition in LGR7 knockout miceOrigin of INSL3-mediated testicular descent in therian mammalsRegulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogsMutations in the insulin-like factor 3 receptor are associated with osteoporosis.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsSynthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization.LGR8 signal activation by the relaxin-like factor.Fetal Leydig cell origin and development.Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevisDevelopment of a selective agonist for relaxin family peptide receptor 3.Impact of methoxyacetic acid on mouse Leydig cell gene expressionIn utero exposure to an AR antagonist plus an inhibitor of fetal testosterone synthesis induces cumulative effects on F1 male rats.Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways.INSL3/RXFP2 signaling in testicular descent.The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor.Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects.Examination of relaxin and its receptors expression in pig gametes and embryos.Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.The human relaxin receptor (LGR7): expression in the fetal membranes and placenta.Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathwaysUterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2The orl rat is more responsive to methacholine challenge than wild typeInternational Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.The minimal active structure of human relaxin-2
P2860
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P2860
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
description
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im August 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/08/30)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/08/30)
@nl
наукова стаття, опублікована в серпні 2002
@uk
name
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@ast
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@en
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@nl
type
label
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@ast
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@en
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@nl
prefLabel
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@ast
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@en
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@nl
P2093
P2860
P3181
P356
P1476
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
@en
P2093
Aaron J W Hsueh
Hirotaka Matsumi
Jae-Sook Roh
Jin Kumagai
Sheau Yu Hsu
P2860
P304
31283-31286
P3181
P356
10.1074/JBC.C200398200
P407
P577
2002-07-11T00:00:00Z