Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent - sprookjes - yvandenbroek - TriplyDB

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

http://www.wikidata.org/entity/Q28584148

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Tissue-type plasminogen activator is a neuroprotectant in the central nervous system Retina Is Protected by Neuroserpin from Ischemic/Reperfusion-Induced Injury Independent of Tissue-Type Plasminogen Activator Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB Tissue plasminogen activator is a potent activator of PDGF-CC Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator Neuroserpin protects neurons from ischemia-induced plasmin-mediated cell death independently of tissue-type plasminogen activator inhibition.The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity Tissue plasminogen activator and seizures: a clot-buster's secret life.Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons.Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management?Identification of a neurovascular signaling pathway regulating seizures in mice A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator.Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13 Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.Extracellular matrix in plasticity and epileptogenesis.The perineuronal net component of the extracellular matrix in plasticity and epilepsy Beta-amyloidolysis and glutathione in Alzheimer's disease.Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells.pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization.Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery.Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

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Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

http://www.wikidata.org/entity/Q28584148

description

2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հունիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2002

@ast

im Juni 2002 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2002/06/01)

@sk

vědecký článek publikovaný v roce 2002

@cs

wetenschappelijk artikel (gepubliceerd op 2002/06/01)

@nl

наукова стаття, опублікована в червні 2002

@uk

مقالة علمية (نشرت في يونيو 2002)

@ar

name

Regulation of seizure spreadin ...... tor is plasminogen-independent

@ast

Regulation of seizure spreadin ...... tor is plasminogen-independent

@en

Regulation of seizure spreadin ...... tor is plasminogen-independent

@nl

type

label

Regulation of seizure spreadin ...... tor is plasminogen-independent

@ast

Regulation of seizure spreadin ...... tor is plasminogen-independent

@en

Regulation of seizure spreadin ...... tor is plasminogen-independent

@nl

prefLabel

Regulation of seizure spreadin ...... tor is plasminogen-independent

@ast

Regulation of seizure spreadin ...... tor is plasminogen-independent

@en

Regulation of seizure spreadin ...... tor is plasminogen-independent

@nl

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Journal of Clinical Investigation

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Regulation of seizure spreadin ...... tor is plasminogen-independent

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Daniel A. Lawrence

http://www.w3.org/2001/XMLSchema#string

David Mitola

http://www.w3.org/2001/XMLSchema#string

Elizabeth Moore

http://www.w3.org/2001/XMLSchema#string

Jiang-Young Wu

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Manuel Yepes

http://www.w3.org/2001/XMLSchema#string

Maria Sandkvist

http://www.w3.org/2001/XMLSchema#string

Timothy A. Coleman

http://www.w3.org/2001/XMLSchema#string

P2860

Familial dementia caused by polymerization of mutant neuroserpin

Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival

Biochemical characterization of a neuroserpin variant associated with hereditary dementia

The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin.

Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy.

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

Directed polar secretion of protease from single cells of Vibrio cholerae via the type II secretion pathway.

Familial encephalopathy with neuroserpin inclusion bodies

The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

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1571–1578

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scholarly article

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772323

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10.1172/JCI0214308

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10.1172/JCI14308

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P407

P433

12

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109

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Thomas H. Bugge

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2002-06-01T00:00:00Z

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12070304

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151009

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