Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation
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Evidence that SOX2 overexpression is oncogenic in the lungSOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomasThe role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lungDifferentiated type II pneumocytes can be reprogrammed by ectopic Sox2 expressionPulmonary adenocarcinoma: a renewed entity in 2011Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1bThe PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesisSox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium.Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells.Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung.B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryoGeneration of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells.Molecular pathways and therapeutic targets in lung cancerGenomics of squamous cell lung cancerLung cancer stem cell: new insights on experimental models and preclinical data.Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinomaSOX2 hypomorphism disrupts development of the prechordal floor and optic cupTransforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells.SOX2 regulates acinar cell development in the salivary gland.Multipotent capacity of immortalized human bronchial epithelial cellsTwo nested developmental waves demarcate a compartment boundary in the mouse lungDevelopmental programs of lung epithelial progenitors: a balanced progenitor model.Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation.Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.True 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugsMyb permits multilineage airway epithelial cell differentiation.SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell stateHypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung developmentHigh SOX2 levels predict better outcome in non-small cell lung carcinomas.Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancerAbnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysisSox2 activates cell proliferation and differentiation in the respiratory epithelium.Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development.Identification of logic relationships between genes and subtypes of non-small cell lung cancer.Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.Productive Infection of Human Embryonic Stem Cell-Derived NKX2.1+ Respiratory Progenitors with Human Rhinovirus.β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.Clinical significance of OCT4 and SOX2 protein expression in cervical cancer.
P2860
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P2860
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation
description
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/05/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/05/01)
@nl
наукова стаття, опублікована в травні 2008
@uk
مقالة علمية (نشرت في مايو 2008)
@ar
name
Sox2 is important for two cruc ...... pithelial cell differentiation
@ast
Sox2 is important for two cruc ...... pithelial cell differentiation
@en
Sox2 is important for two cruc ...... pithelial cell differentiation
@nl
type
label
Sox2 is important for two cruc ...... pithelial cell differentiation
@ast
Sox2 is important for two cruc ...... pithelial cell differentiation
@en
Sox2 is important for two cruc ...... pithelial cell differentiation
@nl
prefLabel
Sox2 is important for two cruc ...... pithelial cell differentiation
@ast
Sox2 is important for two cruc ...... pithelial cell differentiation
@en
Sox2 is important for two cruc ...... pithelial cell differentiation
@nl
P2093
P3181
P1476
Sox2 is important for two cruc ...... pithelial cell differentiation
@en
P2093
Anne de Munck
Cristina Gontan
Frank Grosveld
Marcel Vermeij
Robbert Rottier
P304
P3181
P356
10.1016/J.YDBIO.2008.02.035
P407
P50
P577
2008-05-01T00:00:00Z