SCL is required for normal function of short-term repopulating hematopoietic stem cells
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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesisAdult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survivalThe essential haematopoietic transcription factor Scl is also critical for neuronal developmentModeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors.Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice.Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance.Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators.Launching the T-cell-lineage developmental programmeGenetic interaction between Kit and Scl.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expressionThe transcriptional programme controlled by Runx1 during early embryonic blood development.Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia geneLack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity.The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.Specification of neurotransmitter identity by Tal1 in thalamic nuclei.Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective.The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.The Role of TAL1 in Hematopoiesis and Leukemogenesis.
P2860
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P2860
SCL is required for normal function of short-term repopulating hematopoietic stem cells
description
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
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im Januar 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/05/01)
@sk
vědecký článek publikovaný v roce 2004
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wetenschappelijk artikel (gepubliceerd op 2004/05/01)
@nl
наукова стаття, опублікована в травні 2004
@uk
مقالة علمية (نشرت في مايو 2004)
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name
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@ast
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@en
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@nl
type
label
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@ast
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@en
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@nl
prefLabel
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@ast
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@en
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@nl
P2093
P1433
P1476
SCL is required for normal function of short-term repopulating hematopoietic stem cells
@en
P2093
C Glenn Begley
Leonie J Van Stekelenburg
Lorraine Robb
Mark A Hall
Stephen M Jane
P304
P356
10.1182/BLOOD-2003-09-3202
P407
P577
2004-01-15T00:00:00Z