Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice
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Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington diseaseThe Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactionsModelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal developmentNeuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sortingLoss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in miceLoss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiationBrainstem Hap1-Ahi1 is involved in insulin-mediated feeding controlAhi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle traffickingNeural mechanisms underlying stress resilience in Ahi1 knockout mice: relevance to neuropsychiatric disordersAHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders.Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the SH3 domain of human AHI1Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestineAlterations in the expression of a neurodevelopmental gene exert long-lasting effects on cognitive-emotional phenotypes and functional brain networks: translational evidence from the stress-resilient Ahi1 knockout mouse.Joubert syndrome: insights into brain development, cilium biology, and complex disease.Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study.A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.Abelson helper integration site-1 gene variants on major depressive disorder and bipolar disorderHuntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation.The influence of AHI1 variants on the diagnosis and treatment outcome in schizophreniaPostnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice.Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C receptor.Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex.Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans.A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.Huntingtin associated protein 1 and its functions.Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1.Endosomal system genetics and autism spectrum disorders: A literature review.Expression changes of hypothalamic Ahi1 in mice brain: implication in sensing insulin signaling.DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice.
P2860
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P2860
Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/01)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية نشرت في أغسطس 2008 حول موضوع: دماغ
@ar
name
Huntingtin-associated protein ...... brainstem development in mice
@ast
Huntingtin-associated protein ...... brainstem development in mice
@en
Huntingtin-associated protein ...... brainstem development in mice
@nl
type
label
Huntingtin-associated protein ...... brainstem development in mice
@ast
Huntingtin-associated protein ...... brainstem development in mice
@en
Huntingtin-associated protein ...... brainstem development in mice
@nl
prefLabel
Huntingtin-associated protein ...... brainstem development in mice
@ast
Huntingtin-associated protein ...... brainstem development in mice
@en
Huntingtin-associated protein ...... brainstem development in mice
@nl
P2093
P2860
P921
P3181
P356
P1476
Huntingtin-associated protein ...... brainstem development in mice
@en
P2093
Chuan-En Wang
Dongmei Cheng
Guoqing Sheng
Junmin Peng
Shi-Hua Li
Xiao-Jiang Li
Xiaoyan Jiang
Yung-Feng Lin
P2860
P304
P3181
P356
10.1172/JCI35339
P407
P50
P577
2008-08-01T00:00:00Z