The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
about
Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W speciesMEK and TGF-beta Inhibition Promotes Reprogramming without the Use of Transcription FactorGenetic exploration of the exit from self-renewal using haploid embryonic stem cellsBrf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinaseSequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells.MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cellsFunctional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript.Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.Bacterial delivery of nuclear proteins into pluripotent and differentiated cellsFour simple rules that are sufficient to generate the mammalian blastocystMaking the blastocyst: lessons from the mouseMyc represses primitive endoderm differentiation in pluripotent stem cells.Totipotent embryonic stem cells arise in ground-state culture conditions.NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.The different shades of mammalian pluripotent stem cells.Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineageMicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm.Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass.Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1.Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotencyA model-based analysis of culture-dependent phenotypes of mESCs.Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos.Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation.Molecular basis of Mammalian embryonic stem cell pluripotency and self-renewal.Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell statesRegulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factorFibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors.TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium.Cell Fate Specification Based on Tristability in the Inner Cell Mass of Mouse Blastocysts.Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and NanogUbiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells.Integrins are required for the differentiation of visceral endodermStable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor.Heparan sulfate: a key regulator of embryonic stem cell fate.Induced pluripotent stem cells: fundamentals and applications of the reprogramming process and its ramifications on regenerative medicine.Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos
P2860
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P2860
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
description
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Oktober 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/10/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/10/01)
@nl
наукова стаття, опублікована в жовтні 2006
@uk
مقالة علمية (نشرت في أكتوبر 2006)
@ar
name
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@ast
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@en
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@nl
type
label
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@ast
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@en
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@nl
prefLabel
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@ast
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@en
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@nl
P2093
P2860
P356
P1476
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
@en
P2093
Naohiro Terada
Sarah M. Kehoe
Takashi Hamazaki
Toru Nakano
P2860
P304
P356
10.1128/MCB.00508-06
P407
P577
2006-10-01T00:00:00Z