Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
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NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defectsSubfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergenceA conditional knockout resource for the genome-wide study of mouse gene functionGremlin enhances the determined path to cardiomyogenesisHigh throughput sequencing approaches to mutation discovery in the mouseEvaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus DrosophilaHand/foot splitting and the 're-evolution' of mesopodial skeletal elements during the evolution and radiation of chameleonsFunctional analysis of limb transcriptional enhancers in the mouseKidney development in the absence of Gdnf and Spry1 requires Fgf10.Formins in development: orchestrating body plan origami.Evolution of vertebrate appendicular structures: Insight from genetic and palaeontological data.A GREM1 gene variant associates with diabetic nephropathy.Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysisLong-range control of gene expression: emerging mechanisms and disruption in disease.Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds.Topology of mammalian developmental enhancers and their regulatory landscapes.TRACER: a resource to study the regulatory architecture of the mouse genomeSHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling.Enhanced neuronal Met signalling levels in ALS mice delay disease onset.Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters.A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genesExtensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis.Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene ExpressionMeta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene.Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesisA genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbFrom remote enhancers to gene regulation: charting the genome's regulatory landscapes.Formin1 disruption confers oligodactylism and alters Bmp signaling.Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10.Formins: emerging players in the dynamic plant cell cortexThe Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic DistancesA Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Transcriptional activators and activation mechanisms.Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences.3D genomics imposes evolution of the domain model of eukaryotic genome organization.John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality.Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.Association between polymorphisms at the GREM1 locus and the risk of nonsyndromic cleft lip with or without cleft palate in the Polish population.
P2860
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P2860
Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
description
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Juli 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/07/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/07/01)
@nl
наукова стаття, опублікована в липні 2004
@uk
مقالة علمية (نشرت في يوليو 2004)
@ar
name
Mouse limb deformity mutations ...... equired for Gremlin expression
@ast
Mouse limb deformity mutations ...... equired for Gremlin expression
@en
Mouse limb deformity mutations ...... equired for Gremlin expression
@nl
type
label
Mouse limb deformity mutations ...... equired for Gremlin expression
@ast
Mouse limb deformity mutations ...... equired for Gremlin expression
@en
Mouse limb deformity mutations ...... equired for Gremlin expression
@nl
prefLabel
Mouse limb deformity mutations ...... equired for Gremlin expression
@ast
Mouse limb deformity mutations ...... equired for Gremlin expression
@en
Mouse limb deformity mutations ...... equired for Gremlin expression
@nl
P2093
P2860
P50
P356
P1433
P1476
Mouse limb deformity mutations ...... equired for Gremlin expression
@en
P2093
Anna-Pavlina G. Haramis
Antonella Galli
Christian Klasen
Lia Panman
Rosanna Dono
Sylwia Kuc
William Mansfield
P2860
P304
P356
10.1101/GAD.299904
P577
2004-07-01T00:00:00Z