Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein
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NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthOverexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunitsDysfunctions of neuronal and glial intermediate filaments in diseaseIdentification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganizationPlectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeletonGene targeting studies begin to reveal the function of neurofilament proteinsAxon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron PolarityStable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosisTargeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiologyRequirement of heavy neurofilament subunit in the development of axons with large calibersTwo distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filamentsDisruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunitsAbsence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament contentRNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degenerationNeurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.Intermediate filaments: a historical perspectiveThe emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Neurobehavioral characteristics of mice with modified intermediate filament genes.Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQStructure-function analysis of the glioma targeting NFL-TBS.40-63 peptide corresponding to the tubulin-binding site on the light neurofilament subunitAxonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.Amyotrophic lateral sclerosis: human challenge for neuroscienceNeurofilament light polypeptide gene N98S mutation in mice leads to neurofilament network abnormalities and a Charcot-Marie-Tooth Type 2E phenotype.Electron microscopic and proteomic comparison of terminal branches of the trigeminal nerve in patients with and without migraine headaches.Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.Axon diameter and axonal transport: In vivo and in vitro effects of androgens.Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament proteinA Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases.Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation.Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration.Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transportNeurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase.Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutantNeurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutationEarly-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus.Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.
P2860
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P2860
Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein
description
1994 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im Februar 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/02/01)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/02/01)
@nl
наукова стаття, опублікована в лютому 1994
@uk
مقالة علمية (نشرت في فبراير 1994)
@ar
name
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@ast
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@en
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@nl
type
label
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@ast
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@en
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@nl
prefLabel
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@ast
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@en
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@nl
P921
P3181
P1433
P1476
Neurofilament-deficient axons ...... a-galactosidase fusion protein
@en
P2093
A. Peterson
P304
P3181
P356
10.1016/0896-6273(94)90280-1
P407
P50
P577
1994-02-01T00:00:00Z