Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
about
Taurine: the appeal of a safe amino acid for skeletal muscle disordersThe potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophyModulating exercise-induced hormesis: Does less equal more?Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunitiesGenetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophyThe hallmarks of agingGrowth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive graspingBGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen SpeciesReduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophyTherapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injuryTHADA Regulates the Organismal Balance between Energy Storage and Heat Production.G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle.Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology.High-throughput FRET assay yields allosteric SERCA activatorsDystrophin is a tumor suppressor in human cancers with myogenic programs.Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regenerationHigh throughput screening in duchenne muscular dystrophy: from drug discovery to functional genomicsVBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivoEffects of Dantrolene Therapy on Disease Phenotype in Dystrophin Deficient mdx Mice.FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.Can endurance exercise preconditioning prevention disuse muscle atrophy?Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy.SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice.A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.Disease-proportional proteasomal degradation of missense dystrophinsLipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy.Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1DProfiling of age-related changes in the tibialis anterior muscle proteome of the mdx mouse model of dystrophinopathyAbsence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers.Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse
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P2860
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
description
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2012
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scientific journal article
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vedecký článok (publikovaný 2012/04/04)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/04/04)
@nl
наукова стаття, опублікована у квітні 2012
@uk
مقالة علمية (نشرت في 4-4-2012)
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name
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@ast
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@en
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@nl
type
label
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@ast
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@en
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@nl
prefLabel
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@ast
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@en
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
@nl
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P50
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P1476
Hsp72 preserves muscle functio ...... muscular dystrophy
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P2093
Chris van der Poel
Darren C Henstridge
Jonathan D Schertzer
Kay E Davies
Mark A Febbraio
Stefan M Gehrig
Timothy A Sayer
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P2888
P304
P3181
P356
10.1038/NATURE10980
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P577
2012-04-04T00:00:00Z
P6179
1033101926