Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
about
Sonic hedgehog signaling in the development of the mouse hypothalamusUnique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephalyCdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in miceA dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote faceSix3 regulates optic nerve development via multiple mechanisms.Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and PlasticityEye development and retinogenesisEvolution and development of interhemispheric connections in the vertebrate forebrainMechanisms that underlie co-variation of the brain and faceDisruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening.Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalingDirect transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancerCurrent recommendations for the molecular evaluation of newly diagnosed holoprosencephaly patientsThe molecular genetics of holoprosencephaly.Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.Chromosome conformation capture uncovers potential genome-wide interactions between human conserved non-coding sequences.Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers.Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.Molecular regulation of the developing commissural plateLarge-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position.Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud.Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.TRACER: a resource to study the regulatory architecture of the mouse genomeMassively parallel decoding of mammalian regulatory sequences supports a flexible organizational model.Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.Autism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum.Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish.Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling.Lens development depends on a pair of highly conserved Sox21 regulatory elementsClinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and functionInhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.Enhancer turnover and conserved regulatory function in vertebrate evolution.Cis-regulatory mutations in human disease.The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis.
P2860
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P248
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P2860
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
description
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2008
@ast
im November 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/11/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/11/01)
@nl
наукова стаття, опублікована в листопаді 2008
@uk
name
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@ast
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@en
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@nl
type
label
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@ast
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@en
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@nl
prefLabel
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@ast
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@en
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@nl
P2093
P2860
P921
P356
P1433
P1476
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
@en
P2093
Anastasia Yocum
Christele Dubourg
Douglas J. Epstein
Erich Roessler
Federico Coluccio Leskow
Guillermo Oliver
Maximilian Muenke
P2860
P2888
P304
P356
10.1038/NG.230
P407
P577
2008-11-01T00:00:00Z
P5875
P6179
1012034353