The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts
about
SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinaseGrb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesisMutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson diseaseThe Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptorRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsIdentification of Grb10 as a direct substrate for members of the Src tyrosine kinase familyEvidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gammaInteraction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesTwo novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signalingmGrb10 interacts with Nedd4Identification of the rat adapter Grb14 as an inhibitor of insulin actionsInhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization.Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.Meta-analyses of seven GIGYF2 polymorphisms with Parkinson's diseaseLigand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function.Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant miceDisruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome geneInsulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform AMice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.The insulin receptor: a new target for cancer therapy.Grb10 and Grb14: enigmatic regulators of insulin action--and more?Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans.Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasisGrb10 is a dual regulator of receptor tyrosine kinase signaling.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaGrowth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Structure and function of the insulin-like growth factor I receptor.APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes.The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors.Inhibition of FGF receptor signalling in Xenopus oocytes: differential effect of Grb7, Grb10 and Grb14.Insulin Receptor Isoforms in Physiology and Disease: An Updated View.Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.The adaptors Grb10 and Grb14 are calmodulin-binding proteins.
P2860
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P2860
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts
description
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im März 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/03/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/03/01)
@nl
наукова стаття, опублікована в березні 1997
@uk
مقالة علمية (نشرت في مارس 1997)
@ar
name
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@ast
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@en
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@nl
type
label
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@ast
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@en
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@nl
prefLabel
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@ast
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@en
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@nl
P2093
P2860
P356
P1476
The adapter protein Grb10 asso ...... receptor in mouse fibroblasts
@en
P2093
J. A. Baquero
J. C. Chow
L. Laviola
R. J. Smith
P2860
P304
P356
10.1172/JCI119246
P407
P577
1997-03-01T00:00:00Z