Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis
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NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulumDown-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing miceEndoplasmic reticulum stress and inflammation in the central nervous systemContribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunctionProtective effects of incensole acetate on cerebral ischemic injury.Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's diseaseHippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease.A mitocentric view of Alzheimer's disease suggests multi-faceted treatmentsER calcium and Alzheimer's disease: in a state of flux.Endoplasmic reticulum Ca(2+) handling in excitable cells in health and diseasePresenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologicallyThe mitochondrial death pathway: a promising therapeutic target in diseasesExpansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.Alzheimer's disease: A hypothesis on pathogenesis.Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell deathNanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injuryPresenilin: RIP and beyond.Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unitPresenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slicesOrais and STIMs: physiological mechanisms and diseaseSporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes.A new and simple approach for genotyping Alzheimer's disease presenilin-1 mutant knock-in mice.Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aβ deposits: effect of immunoglobulinControl of intracellular calcium signaling as a neuroprotective strategyDantrolene, a treatment for Alzheimer disease?Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouseMechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation.
P2860
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P2860
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/15)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/15)
@nl
наукова стаття, опублікована в лютому 2000
@uk
مقالة علمية (نشرت في 15-2-2000)
@ar
name
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@ast
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@en
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@nl
type
label
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@ast
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@en
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@nl
prefLabel
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@ast
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@en
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@nl
P2093
P921
P1476
Presenilin-1 mutation increase ...... perturbed calcium homeostasis
@en
P2093
P304
P356
10.1523/JNEUROSCI.20-04-01358.2000
P407
P577
2000-02-15T00:00:00Z