Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
about
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase geneAngptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophagesEndothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in miceHeterogeneity in the lymphatic vascular system and its originDevelopment of the mammalian lymphatic vasculatureThe gut-adipose-liver axis in the metabolic syndromeLymphatic fate specification: an ERK-controlled transcriptional programRole of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney DevelopmentRestoration of lymphatic function rescues obesity in Prox1-haploinsufficient miceChronic high-fat diet impairs collecting lymphatic vessel function in miceLymphatic regulator PROX1 determines Schlemm's canal integrity and identityPancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreasCanal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activityProx1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesisLymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activityProx1 maintains muscle structure and growth in the developing heartProx1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expressionPhotoacoustic lymphatic imaging with high spatial-temporal resolution.Photothermal optical lock-in optical coherence tomography for in vivo imagingPreclinical lymphatic imaging.New horizons for imaging lymphatic function.Lymphatic imaging in humans with near-infrared fluorescenceNear-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and UpdateLymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.Emerging lymphatic imaging technologies for mouse and man.An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease.Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosityA new mouse model to study acquired lymphedemaRare adipose disorders (RADs) masquerading as obesity.Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.IL-6 regulates adipose deposition and homeostasis in lymphedema.Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.Prox1 regulates the notch1-mediated inhibition of neurogenesis.Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flowObesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema.Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculatureThe lymphatic system in health and disease.
P2860
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P2860
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
description
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2005
@ast
im Oktober 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/10/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/10/01)
@nl
наукова стаття, опублікована в жовтні 2005
@uk
name
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@ast
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@en
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@nl
type
label
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@ast
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@en
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@nl
prefLabel
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@ast
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@en
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
@en
P2093
Guillermo Oliver
Kelli Boyd
Mark W Sleeman
Marlys H Witte
Miriam E Dillard
Nicole C Johnson
R Sathish Srinivasan
P2860
P2888
P304
P3181
P356
10.1038/NG1642
P407
P577
2005-09-18T00:00:00Z