Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
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Krüppel-like factors: three fingers in controlMammalian Krüppel-like factors in health and diseasesSLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activatorDll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cellsTranscription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiationKrüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCsBasonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epitheliumSmooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.Development of novel filtering criteria to analyze RNA-sequencing data obtained from the murine ocular lens during embryogenesisKLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial-Mesenchymal Transition.High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor.Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbusMouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4.Genetic dependence of central corneal thickness among inbred strains of mice.Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expressionKlf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea.Krüppel-like factor 4 mediates lysophosphatidic acid-stimulated migration and proliferation of PC3M prostate cancer cells.Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier functionRegulation of corneal epithelial barrier function by Kruppel-like transcription factor 4.Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas.The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells.Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea.TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context.Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber."Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblastsOverexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sitesEsophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagusSpatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis.Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development.Krüppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 ExpressionCorneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health.Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier.
P2860
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P2860
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
description
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Januar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/01/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/01/01)
@nl
наукова стаття, опублікована в січні 2007
@uk
مقالة علمية (نشرت عام 2007)
@ar
name
Conditional deletion of the mo ...... s of conjunctival goblet cells
@ast
Conditional deletion of the mo ...... s of conjunctival goblet cells
@en
Conditional deletion of the mo ...... s of conjunctival goblet cells
@nl
type
label
Conditional deletion of the mo ...... s of conjunctival goblet cells
@ast
Conditional deletion of the mo ...... s of conjunctival goblet cells
@en
Conditional deletion of the mo ...... s of conjunctival goblet cells
@nl
prefLabel
Conditional deletion of the mo ...... s of conjunctival goblet cells
@ast
Conditional deletion of the mo ...... s of conjunctival goblet cells
@en
Conditional deletion of the mo ...... s of conjunctival goblet cells
@nl
P2093
P2860
P356
P1476
Conditional deletion of the mo ...... s of conjunctival goblet cells
@en
P2093
Jonathan P. Katz
Joram Piatigorsky
Klaus H. Kaestner
Mary A. Crawford
Shivalingappa K. Swamynathan
P2860
P304
P356
10.1128/MCB.00846-06
P407
P577
2007-01-01T00:00:00Z