The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
about
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensationGranzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysisThe subunit CSN6 of the COP9 signalosome is cleaved during apoptosisCaspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelopeCaspases: the executioners of apoptosisCaspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosisRecombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of themMolecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteasesDeath, autoantigen modifications, and tolerance.Nuclear lamins and oxidative stress in cell proliferation and longevitySubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6A designed redox-controlled caspaseAllosteric peptides bind a caspase zymogen and mediate caspase tetramerizationBAG3: a new player in the heart failure paradigmCaspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosisERICE, a novel FLICE-activatable caspaseHepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signalingA whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CInterleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cellsCaspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspasesCleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cellsCleavage of focal adhesion kinase by caspases during apoptosisCaspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosisA quantitative method for the specific assessment of caspase-6 activity in cell cultureA combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisCaspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Activation of the caspase cascade during Stx1-induced apoptosis in Burkitt's lymphoma cells.Definition and redesign of the extended substrate specificity of granzyme B.Monocytes are highly sensitive to clostridium difficile toxin A-induced apoptotic and nonapoptotic cell deathApoptosis induction in Jurkat cells and sCD95 levels in women's sera are related with the risk of developing cervical cancerCombined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection.Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells.T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria.Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.Granzyme A activates another way to dieRestoration of UV sensitivity in UV-resistant HeLa cells by antisense-mediated depletion of damaged DNA-binding protein 2 (DDB2).
P2860
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P2860
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
description
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Juli 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/07/12)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/07/12)
@nl
наукова стаття, опублікована в липні 1996
@uk
name
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@ast
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@en
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@nl
type
label
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@ast
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@en
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@nl
prefLabel
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@ast
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@en
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@nl
P2093
P2860
P356
P1476
The CED-3/ICE-like protease Mc ...... es the death substrate lamin A
@en
P2093
A. M. Chinnaiyan
C. J. Froelich
V. M. Dixit
P2860
P304
16443–16446
P356
10.1074/JBC.271.28.16443
P407
P50
P577
1996-07-12T00:00:00Z