Negative regulation by HLA-DO of MHC class II-restricted antigen processing
about
Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesisHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismAltered major histocompatibility complex class II peptide loading in H2-O-deficient miceProteases involved in MHC class II antigen presentationThe impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesRoles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance inductionCytomegalovirus infection enhances the immune response to influenza.The binding of TAPBPR and Tapasin to MHC class I is mutually exclusive.Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.Pathways of antigen processing.Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.Peptide exchange in MHC molecules.The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapyOn the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.H2-O, a MHC class II-like protein, sets a threshold for B-cell entry into germinal centers.Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules.Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.Binding interactions between peptides and proteins of the class II major histocompatibility complex.Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.Functional HLA-DM on the surface of B cells and immature dendritic cells.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains.The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathwayCompartmentalization of class II antigen presentation: contribution of cytoplasmic and endosomal processing.Right place, right time, right peptide: DO keeps DM focused.pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cellsDM determines the cryptic and immunodominant fate of T cell epitopes.Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.Ubiquitination of HLA-DO by MARCH family E3 ligases.GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity.MHC class II molecules on the move for successful antigen presentation.MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes.MHC class II transport at a glance
P2860
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P2860
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
description
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1997
@ast
im Oktober 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/10/03)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/10/03)
@nl
наукова стаття, опублікована в жовтні 1997
@uk
name
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@ast
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@en
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@nl
type
label
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@ast
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@en
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@nl
prefLabel
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@ast
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@en
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@nl
P2093
P2860
P3181
P1433
P1476
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
@en
P2093
C. Hammond
D. B. Sant'Angelo
L. K. Denzin
M. J. Surman
P. Cresswell
P2860
P304
P3181
P356
10.1126/SCIENCE.278.5335.106
P407
P577
1997-10-03T00:00:00Z