Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity
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Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell functionCloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasminThe tertiary structure and domain organization of coagulation factor VIIICysteamine enhances the procoagulant activity of Factor VIII-East Hartford, a dysfunctional protein due to a light chain thrombin cleavage site mutation (arginine-1689 to cysteine)Extracellular release of the 'differentiation enhancing factor', a HMG1 protein type, is an early step in murine erythroleukemia cell differentiationThe RING finger protein SNURF is a bifunctional protein possessing DNA binding activityDifferential proteolytic activation of factor VIII-von Willebrand factor complex by thrombinChanges in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IXSurface-mediated control of blood coagulation: the role of binding site densities and platelet depositionStructural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics studyLocalization of a factor VIII-inhibiting antibody epitope to a region between residues 338 and 362 of factor VIII heavy chain.Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.Electron microscopy of human factor V and factor VIII: correlation of morphology with domain structure and localization of factor V activation fragments.Direct characterization of factor VIII in plasma: detection of a mutation altering a thrombin cleavage site (arginine-372----histidine).Haemophilia A and haemophilia B: molecular insightsRegulation of the protein C anticoagulant and antiinflammatory pathways.Vagus nerve stimulation regulates hemostasis in swine.Effects of replacement of factor VIII amino acids Asp519 and Glu665 with Val on plasma survival and efficacy in vivo.The molecular basis of factor V and VIII procofactor activationBlood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation.A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIIIA single chain variant of factor VIII Fc fusion protein retains normal in vivo efficacy but exhibits altered in vitro activity.Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitroEngineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variantGene therapy for hemophilia A: production of therapeutic levels of human factor VIII in vivo in mice.The molecular basis of hemophilia A.Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.A brief historical review of the waterfall/cascade of blood coagulation.Factor VIII-East Hartford (arginine 1689 to cysteine) has procoagulant activity when separated from von Willebrand factor.PEGylation of a factor VIII-phosphatidylinositol complex: pharmacokinetics and immunogenicity in hemophilia A mice.Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase.Evaluation of von Willebrand factor phenotypes and genotypes in Hemophilia A patients with and without identified F8 mutationsSequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombinFunctional assembly of intrinsic coagulation proteases on monocytes and platelets. Comparison between cofactor activities induced by thrombin and factor XaRegulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system
P2860
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P2860
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity
description
1986 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1986
@ast
im Januar 1986 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1986/01/28)
@sk
vědecký článek publikovaný v roce 1986
@cs
wetenschappelijk artikel (gepubliceerd op 1986/01/28)
@nl
наукова стаття, опублікована в січні 1986
@uk
مقالة علمية (نشرت في 28-1-1986)
@ar
name
Proteolytic processing of huma ...... factor VIII coagulant activity
@ast
Proteolytic processing of huma ...... factor VIII coagulant activity
@en
Proteolytic processing of huma ...... factor VIII coagulant activity
@nl
type
label
Proteolytic processing of huma ...... factor VIII coagulant activity
@ast
Proteolytic processing of huma ...... factor VIII coagulant activity
@en
Proteolytic processing of huma ...... factor VIII coagulant activity
@nl
prefLabel
Proteolytic processing of huma ...... factor VIII coagulant activity
@ast
Proteolytic processing of huma ...... factor VIII coagulant activity
@en
Proteolytic processing of huma ...... factor VIII coagulant activity
@nl
P2093
P356
P1433
P1476
Proteolytic processing of huma ...... factor VIII coagulant activity
@en
P2093
G. A. Vehar
H. Rodriguez
P304
P356
10.1021/BI00350A035
P407
P577
1986-01-28T00:00:00Z