Structure-activity exploration of a small-molecule Lipid II inhibitor

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Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics Computer-Aided Drug Design Methods.

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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2015年論文

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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P1476

Structure-activity exploration of a small-molecule Lipid II inhibitor

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P2093

Erik P H de Leeuw

http://www.w3.org/2001/XMLSchema#string

Jay Chauhan

http://www.w3.org/2001/XMLSchema#string

Steven Fletcher

http://www.w3.org/2001/XMLSchema#string

Steven M Kwasny

http://www.w3.org/2001/XMLSchema#string

Timothy J Opperman

http://www.w3.org/2001/XMLSchema#string

Wenbo Yu

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P2860

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Defensins: antimicrobial peptides of innate immunity

Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types.

Synergy and duality in peptide antibiotic mechanisms.

Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.

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2383-2394

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scholarly article

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2835600

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10.2147/DDDT.S79504

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P407

English

P478

http://www.w3.org/2001/XMLSchema#string

P50

Jing Huang

Alex MacKerell

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2015-04-24T00:00:00Z

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P698

25987836

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P921

drug discovery

P932

4422293

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Structure-activity exploration of a small-molecule Lipid II inhibitor

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P2860

P2860

Structure-activity exploration of a small-molecule Lipid II inhibitor

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type

label

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P1433

P1476

P2093

P2860

P304

P31

P3181

P356

P407

P478

P50

P577

P698

P921

P932

P3181

P356

P1433

P1476

P2093

P2860

P304

P31

P3181

P356

P407

P478

P50

P577

P698

P921

P932