Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses
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Lens β-crystallins: the role of deamidation and related modifications in aging and cataract.Identification of Sequence Similarities among Isomerization Hotspots in Crystallin Proteins.Biophysical chemistry of the ageing eye lens.Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.Identification of amino acid epimerization and isomerization in crystallin proteins by tandem LC-MSSpontaneous cyclization of polypeptides with a penultimate Asp, Asn or isoAsp at the N-terminus and implications for cleavage by aminopeptidase.Engineering D-Amino Acid Containing Collagen Like Peptide at the Cleavage Site of Clostridium histolyticum Collagenase for Its Inhibition.Degradation of an old human protein: age-dependent cleavage of γS-crystallin generates a peptide that binds to cell membranesIsoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?The αA66-80 peptide interacts with soluble α-crystallin and induces its aggregation and precipitation: a contribution to age-related cataract formation.Effect of Mild Heating on Human Lens Epithelial Cells: A Possible Model of Lens Aging.Old proteins and the Achilles heel of mass spectrometry. The role of proteomics in the etiology of human cataract.The etiology of human age-related cataract. Proteins don't last foreverSpontaneous cleavage of proteins at serine and threonine is facilitated by zinc.Old Proteins in Man: A Field in its Infancy.Deuteration protects asparagine residues against racemization.Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate IonAcetic acid can catalyze succinimide formation from aspartic acid residues by a concerted bond reorganization mechanism: a computational study.Age-dependent racemization of serine residues in a human chaperone proteinAge-dependent deamidation of glutamine residues in human γS crystallin: deamidation and unstructured regions.Age-dependent modification of proteins: N-terminal racemization.A Computational Study of the Mechanism of Succinimide Formation in the Asn-His Sequence: Intramolecular Catalysis by the His Side Chain.Racemization at the Asp 58 residue in αA-crystallin from the lens of high myopic cataract patients.Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine.Distinguishing d- and l-aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry.Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism.Separate mechanisms for age-related truncation and racemisation of peptide-bound serine.Can the Fact That Myelin Proteins Are Old and Break down Explain the Origin of Multiple Sclerosis in Some People?
P2860
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P2860
Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Racemisation and human catarac ...... n in age-matched normal lenses
@ast
Racemisation and human catarac ...... n in age-matched normal lenses
@en
Racemisation and human catarac ...... n in age-matched normal lenses
@nl
type
label
Racemisation and human catarac ...... n in age-matched normal lenses
@ast
Racemisation and human catarac ...... n in age-matched normal lenses
@en
Racemisation and human catarac ...... n in age-matched normal lenses
@nl
prefLabel
Racemisation and human catarac ...... n in age-matched normal lenses
@ast
Racemisation and human catarac ...... n in age-matched normal lenses
@en
Racemisation and human catarac ...... n in age-matched normal lenses
@nl
P2860
P3181
P1433
P1476
Racemisation and human catarac ...... n in age-matched normal lenses
@en
P2093
Michelle Yu Sung Hooi
Roger J W Truscott
P2860
P304
P3181
P356
10.1007/S11357-010-9171-7
P407
P577
2011-06-01T00:00:00Z