Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism - sprookjes - yvandenbroek - TriplyDB

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

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NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS Targeting NADPH oxidases for the treatment of cancer and inflammation Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system Redox balance dynamically regulates vascular growth and remodeling Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles The Role of PTEN in Tumor Angiogenesis Reactive oxygen species in inflammation and tissue injury Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue.Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.NADPH oxidases in vascular pathology.The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy.NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells.Roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase in Angiogenesis: Isoform-Specific Effects Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs Updates of reactive oxygen species in melanoma etiology and progression.Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism Regulation of NADPH oxidase 5 by protein kinase C isoforms.Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.Redox signaling at invasive microdomains in cancer cells.Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems The NOX toolbox: validating the role of NADPH oxidases in physiology and disease.Nuclear receptors as modulators of the tumor microenvironment.The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice.Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.Oxidative stress in angiogenesis and vascular disease Hemorrhagic transformation after ischemic stroke in animals and humans

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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

http://www.wikidata.org/entity/Q28743072

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Targeting vascular NADPH oxida ...... ugh a PPARα mediated mechanism

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Christine Deffert

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Curzio Rüegg

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Cédric Szyndralewiez

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Freddy Heitz

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Patrick Page

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Sarah Garrido-Urbani

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P2860

Cell transformation by the superoxide-generating oxidase Mox1

A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1

Reactive oxygen generated by Nox1 triggers the angiogenic switch

Nox1-dependent superoxide production controls colon adenocarcinoma cell migration

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts

Modes of resistance to anti-angiogenic therapy

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

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