Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development - sprookjes - yvandenbroek - TriplyDB

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

http://www.wikidata.org/entity/Q28831339

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Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies Novel drugs that target the metabolic reprogramming in renal cell cancer SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines.From Krebs to clinic: glutamine metabolism to cancer therapy.Attacking the supply wagons to starve cancer cells to death.L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program.ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.SLC Transporters: Structure, Function, and Drug Discovery.Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells.PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence.Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma Drug-induced amino acid deprivation as strategy for cancer therapy.Glutamine transporters in mammalian cells and their functions in physiology and cancer.The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development.Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer.Relation of exposure to amino acids involved in sarcosine metabolic pathway on behavior of non-tumor and malignant prostatic cell lines.PET Tracers Beyond FDG in Prostate Cancer.Metabolic Imaging of Glutamine in Cancer.Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.The Metabolic Phenotype of Prostate Cancer.Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism.Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism.Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer.Structure and allosteric inhibition of excitatory amino acid transporter 1."Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma.Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors.AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.

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P2860

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

http://www.wikidata.org/entity/Q28831339

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2015 nî lūn-bûn

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2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2015 թվականի հուլիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Targeting ASCT2-mediated gluta ...... growth and tumour development

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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The Journal of Pathology

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Targeting ASCT2-mediated gluta ...... growth and tumour development

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Colleen C Nelson

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Cynthia Metierre

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Dadi Gao

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John E J Rasko

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Ladan Fazli

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Mark Schreuder

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Martin Gleave

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Melanie L Lehman

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Michelle van Geldermalsen

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Nicholas J Otte

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P2860

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Bidirectional transport of amino acids regulates mTOR and autophagy

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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278-289

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100496

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10.1002/PATH.4518

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3

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236

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Charles G. Bailey

Martin Sadowski

Rae-Anne Hardie

Justin J L Wong

Natalia Pinello

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2015-07-01T00:00:00Z

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272515745

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25693838

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4973854

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