The canonical Notch signaling pathway: unfolding the activation mechanism. - sprookjes - yvandenbroek - TriplyDB

The canonical Notch signaling pathway: unfolding the activation mechanism.

The canonical Notch signaling pathway: unfolding the activation mechanism.

http://www.wikidata.org/entity/Q29547725

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Liver regeneration signature in hepatitis B virus (HBV)-associated acute liver failure identified by gene expression profiling Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3 Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells The CD46-Jagged1 interaction is critical for human TH1 immunity TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.Botch promotes neurogenesis by antagonizing Notch Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Rabconnectin-3 is a functional regulator of mammalian Notch signaling Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes Radioresistance of Brain Tumors Role of Notch signaling in regulating innate immunity and inflammation in health and disease Glycan Engineering for Cell and Developmental Biology Notch-Mediated Cell Adhesion Notch Signaling in Pancreatic Development Targeting Notch to overcome radiation resistance Notch signaling in prostate cancer: refining a therapeutic opportunity Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?Notch signaling deregulation in multiple myeloma: A rational molecular target Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Coordinating tissue interactions: Notch signaling in cardiac development and disease Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche Targeting the Notch signaling pathway in cancer therapeutics Targeting γ-secretase in breast cancer Hydrogen peroxide sensing, signaling and regulation of transcription factors Multifocal epithelial tumors and field cancerization: stroma as a primary determinant Lymphatic fate specification: an ERK-controlled transcriptional program

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The canonical Notch signaling pathway: unfolding the activation mechanism.

http://www.wikidata.org/entity/Q29547725

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

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name

The canonical Notch signaling pathway: unfolding the activation mechanism.

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The canonical Notch signaling pathway: unfolding the activation mechanism.

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type

label

The canonical Notch signaling pathway: unfolding the activation mechanism.

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The canonical Notch signaling pathway: unfolding the activation mechanism.

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prefLabel

The canonical Notch signaling pathway: unfolding the activation mechanism.

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The canonical Notch signaling pathway: unfolding the activation mechanism.

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Maria Xenia G Ilagan

http://www.w3.org/2001/XMLSchema#string

Raphael Kopan

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of Drosophila MicroRNA targets

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes

The notch regulator MAML1 interacts with p53 and functions as a coactivator

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

Mutations in NOTCH1 cause aortic valve disease

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

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216-233

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10.1016/J.CELL.2009.03.045

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2009-04-01T00:00:00Z

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