Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
about
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosisLINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatinShugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cellsEfficient assembly of de novo human artificial chromosomes from large genomic loci.Reverse engineering of the spindle assembly checkpointThe role of heterochromatin in centromere functionHypoxia and defective apoptosis drive genomic instability and tumorigenesisPhosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisThe functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosisMutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismDimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome depositionMammalian CLASPs are required for mitotic spindle organization and kinetochore alignmentDishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURPZW10 links mitotic checkpoint signaling to the structural kinetochore.The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceClathrin is required for the function of the mitotic spindleSilencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death.Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsIdentification of two novel components of the human NDC80 kinetochore complexA conserved protein network controls assembly of the outer kinetochore and its ability to sustain tensionArchitecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochoreCyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosisThe human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signalingPremitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic stateDeterminants of conformational dimerization of Mad2 and its inhibition by p31cometHuman NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentTimely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3.Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossImplication of ZW10 in membrane trafficking between the endoplasmic reticulum and GolgiA B-Myb complex containing clathrin and filamin is required for mitotic spindle function.Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosisHec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlMTBP plays a crucial role in mitotic progression and chromosome segregation
P2860
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P2860
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@ast
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@en
type
label
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@ast
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@en
prefLabel
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@ast
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@en
P2093
P50
P3181
P1433
P1476
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(03)00115-6
P407
P577
2003-02-01T00:00:00Z