Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders - sprookjes - yvandenbroek - TriplyDB

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

http://www.wikidata.org/entity/Q29614510

about

The epigenetic landscape of acute myeloid leukemia ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2 A decade of exploring the cancer epigenome - biological and translational implications Regulation of chromatin by histone modifications Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes Epigenetic regulators and their impact on therapy in acute myeloid leukemia Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Targeting EZH2 in cancer EZH2 in normal hematopoiesis and hematological malignancies Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications Induced pluripotent stem cell technology for dissecting the cancer epigenome Epigenomics of leukemia: from mechanisms to therapeutic applications Genetics of myeloproliferative neoplasms Epigenomics of cancer - emerging new concepts Involvement of long noncoding RNAs in diseases affecting the central nervous system Mechanisms of epigenetic regulation of leukemia onset and progression Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Chromatin targeting drugs in cancer and immunity Myeloid malignancies: mutations, models and management Advances in the management of myelofibrosis JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?Emerging patterns of somatic mutations in cancer New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice Evolution of the cancer genome Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention EZH2 is highly expressed in pituitary adenomas and associated with proliferation Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain Overgrowth Syndromes.Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 Recurrent DNMT3A mutations in patients with myelodysplastic syndromes Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome.

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

http://www.wikidata.org/entity/Q29614510

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

@zh-tw

2010年论文

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name

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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type

label

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

@ast

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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prefLabel

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

@ast

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Nature Genetics

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Boultwood J

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Bryant C

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Cervantes F

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Chase AJ

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Cross NC

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Duncombe A

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Ernst T

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Grand FH

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Hidalgo-Curtis CE

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Jones AV

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P2860

The Polycomb group protein EZH2 directly controls DNA methylation

Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Detection of large-scale variation in the human genome

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722-6

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scholarly article

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1543518

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10.1038/NG.621

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8

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42

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Andreas Hochhaus

Hans Guenter Drexler

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2010-08-01T00:00:00Z

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45093034

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1045969373

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20601953

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