Comprehensive analysis of kinase inhibitor selectivity - sprookjes - yvandenbroek - TriplyDB

Comprehensive analysis of kinase inhibitor selectivity

Comprehensive analysis of kinase inhibitor selectivity

http://www.wikidata.org/entity/Q29616719

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach Lung inflammation caused by inhaled toxicants: a review Off-label use of targeted therapies in oncology Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging Ten things you should know about protein kinases: IUPHAR Review 14 Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL Bivalent inhibitors of protein kinases Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Targeted therapies in development for non-small cell lung cancer Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?Developing irreversible inhibitors of the protein kinase cysteinome STITCH 4: integration of protein-chemical interactions with user data Using existing drugs as leads for broad spectrum anthelmintics targeting protein kinases KinomeXplorer: an integrated platform for kinome biology studies Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors Affinity-Based Probes Based on Type II Kinase Inhibitors Sequence Determinants of a Specific Inactive Protein Kinase Conformation Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor A Highly Selective Dual Insulin Receptor (IR)/Insulin-like Growth Factor 1 Receptor (IGF-1R) Inhibitor Derived from an Extracellular Signal-regulated Kinase (ERK) Inhibitor A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity Dual kinase-bromodomain inhibitors for rationally designed polypharmacology An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine Comprehensive characterization of the Published Kinase Inhibitor Set Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML A systematic profile of clinical inhibitors responsive to EGFR somatic amino acid mutations in lung cancer: implication for the molecular mechanism of drug resistance and sensitivity.Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4 Targeting the TAM Receptors in Leukemia Development of novel ACK1/TNK2 inhibitors using a fragment-based approach ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

P2860

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P2860

Comprehensive analysis of kinase inhibitor selectivity

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Comprehensive analysis of kinase inhibitor selectivity

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Comprehensive analysis of kinase inhibitor selectivity

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Comprehensive analysis of kinase inhibitor selectivity

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Comprehensive analysis of kinase inhibitor selectivity

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Comprehensive analysis of kinase inhibitor selectivity

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Ciceri P

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Herrgard S

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Treiber DK

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10.1038/NBT.1990

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