DNA polymerases: structural diversity and common mechanisms
about
Direct detection and sequencing of damaged DNA basestRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerasesCrystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerasesPhi29 DNA polymerase residues Tyr59, His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal proteinMutations in human DNA polymerase eta motif II alter bypass of DNA lesionsCoupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy.Replicative DNA polymerasesThe 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityAlkaline phosphatase mono- and diesterase reactions: comparative transition state analysisThe human DINB1 gene encodes the DNA polymerase PolthetaFunctional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptaseConformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.The involvement of the aspartate triad of the active center in all catalytic activities of multisubunit RNA polymerase.Nucleotide modification at the gamma-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase.Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitorsStructural insights into eukaryotic DNA replicationStructure-function studies of DNA polymerase λA rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adductsA Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription ElongationA new paradigm of DNA synthesis: three-metal-ion catalysis.Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.Recombinant viral RdRps can initiate RNA synthesis from circular templates.A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus PolymeraseMechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinesCrystal structure of mammalian poly(A) polymerase in complex with an analog of ATPCrystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymeraseNon-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibitionStructure of a bifunctional DNA primase-polymeraseCrystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesisDual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferasesA structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignmentBypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase etaA relaxed active site after exon ligation by the group I intronInsights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III α-SubunitComparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal IonThe Family X DNA Polymerase from Deinococcus radiodurans Adopts a Non-standard Extended ConformationStructure of the Human Rev1–DNA–dNTP Ternary ComplexStructure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA LesionStructural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase Opposite the 7,8-Dihydro-8-oxo-2'-deoxyguanosine Adduct
P2860
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P2860
DNA polymerases: structural diversity and common mechanisms
description
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Juni 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 18 June 1999)
@en
wetenschappelijk artikel (gepubliceerd op 1999/06/18)
@nl
наукова стаття, опублікована в червні 1999
@uk
مقالة علمية (نشرت في 18-6-1999)
@ar
name
DNA polymerases: structural diversity and common mechanisms
@ast
DNA polymerases: structural diversity and common mechanisms
@en
type
label
DNA polymerases: structural diversity and common mechanisms
@ast
DNA polymerases: structural diversity and common mechanisms
@en
prefLabel
DNA polymerases: structural diversity and common mechanisms
@ast
DNA polymerases: structural diversity and common mechanisms
@en
P2860
P3181
P356
P1476
DNA polymerases: structural diversity and common mechanisms
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.25.17395
P407
P577
1999-06-18T00:00:00Z