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Identification of attractive drug targets in neglected-disease pathogens using an in silico approachStructure of a Burkholderia pseudomallei trimeric autotransporter adhesin headGenomic-scale prioritization of drug targets: the TDR Targets databaseThe Role of Medical Structural Genomics in Discovering New Drugs for Infectious DiseasesResistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferaseThe structure ofPlasmodium vivaxphosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helixIncreasing the structural coverage of tuberculosis drug targetsEfficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein FarnesyltransferaseCharacterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studiesStructure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown functionStructural genomics of pathogenic protozoa: an overviewStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseThe Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine PhosphorylaseThe structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologsDiscovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondiiStructure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphateCrystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/PhosphataseExpression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipelineStructures of phosphopantetheine adenylyltransferase from Burkholderia pseudomalleiStructures of a putative ζ-class glutathione S -transferase from the pathogenic fungus Coccidioides immitisProbing conformational states of glutaryl-CoA dehydrogenase by fragment screeningStructure of a Nudix hydrolase (MutT) in the Mg 2+ -bound state from Bartonella henselae , the bacterium responsible for cat scratch feverStructure of thymidylate kinase from Ehrlichia chaffeensisStructure of triosephosphate isomerase from Cryptosporidium parvumBrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a `putative β-lactamase-like protein' from Brucella melitensisStructure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolutionStructure of fumarate hydratase from Rickettsia prowazekii , the agent of typhus and suspected relative of the mitochondriaSolution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis , the etiological agent responsible for brucellosisNMR structure of an acyl-carrier protein from Borrelia burgdorferiComparative analysis of glutaredoxin domains from bacterial opportunistic pathogensSolution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosisStructure of the cystathionine γ-synthase MetB from Mycobacterium ulceransStructural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitisCombining functional and structural genomics to sample the essential Burkholderia structomeMultiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug designCrystal structure of a macrophage migration inhibitory factor from Giardia lambliaSolution structure of a putative FKBP-type peptidyl-propyl cis–trans isomerase from Giardia lambliaDevelopment of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
P50
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P50
description
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researcher
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հետազոտող
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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Wesley C Van Voorhis
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