Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.
about
Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.Constitutively active Lck kinase in T cells drives antigen receptor signal transductionOpposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module.Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytesSH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cellsNegative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX.Modulation of Lck function through multisite docking to T cell-specific adapter protein.The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderlyLck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of EngagementHow does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.Peripherally induced human regulatory T cells uncouple Kv1.3 activation from TCR-associated signaling.Expression of the T cell-specific adapter protein in human tissues.A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
P2860
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P2860
Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.
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2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2006 թվականի հունվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@ast
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@en
type
label
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@ast
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@en
prefLabel
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@ast
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@en
P2093
P2860
P356
P1476
Essential role of the T cell-s ...... of LCK in peripheral T cells.
@en
P2093
Francesc Marti
Gonzalo G Garcia
Jennifer N MacGregor
Philip D King
Philip E Lapinski
P2860
P304
P356
10.1084/JEM.20051637
P407
P577
2006-01-30T00:00:00Z