Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels.
about
Why reinvent the wheel? Building new proteins based on ready-made partsA -barrel built by the combination of fragments from different foldsEstablishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffoldsExploring Symmetry as an Avenue to the Computational Design of Large Protein DomainsEstablishing catalytic activity on an artificial (βα)8-barrel protein designed from identical half-barrelsProtein design by fusion: implications for protein structure prediction and evolutionEvolutionary relationship of two ancient protein superfoldsTwo independently folding units of Plasmodium profilin suggest evolution via gene fusionAlternative splice variants in TIM barrel proteins from human genome correlate with the structural and evolutionary modularity of this versatile protein foldThe TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated MetabolismDe novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracyStructural and functional modularity of proteins in the de novo purine biosynthetic pathway.Evolution of highly active enzymes by homology-independent recombination.Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus.A fast and precise approach for computational saturation mutagenesis and its experimental validation by using an artificial (βα)8-barrel protein.Biophysics of protein evolution and evolutionary protein biophysicsStructural elements in IGP synthase exclude water to optimize ammonia transfer.Molecular characterization of an α-N-acetylgalactosaminidase from Clonorchis sinensis.Highly diverse protein library based on the ubiquitous (β/α)₈ enzyme fold yields well-structured proteins through in vitro folding selection.Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.Design of symmetric TIM barrel proteins from first principles.Designed protein reveals structural determinants of extreme kinetic stabilityPrecise assembly of complex beta sheet topologies from de novo designed building blocks.Related (βα)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution.Emergence of symmetric protein architecture from a simple peptide motif: evolutionary models.Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design.Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50.Evolution of a protein folding nucleusArtificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases.Evidence showing duplication and recombination of cel genes in tandem from hyperthermophilic Thermotoga sp.Creation of active TIM barrel enzymes through genetic fusion of half-barrel domain constructs derived from two distantly related glycosyl hydrolases.The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme.A highly stable protein chimera built from fragments of different folds.Search for independent (β/α)4 subdomains in a (β/α)8 barrel β-glucosidase.Roles for the two N-terminal (β/α) modules in the folding of a (β/α)₈-barrel protein as studied by fragmentation analysis.The aldo-keto reductase superfamily and its role in drug metabolism and detoxificationA remote but significant sequence homology between glycoside hydrolase clan GH-H and family GH31Highly active enzymes by automated combinatorial backbone assembly and sequence design
P2860
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P2860
Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels.
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@ast
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@en
type
label
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@ast
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@en
prefLabel
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@ast
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@en
P2860
P50
P356
P1476
Mimicking enzyme evolution by ...... rom (betaalpha)4-half-barrels.
@en
P2860
P304
16448-16453
P356
10.1073/PNAS.0405832101
P407
P577
2004-11-11T00:00:00Z