about
RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cellsActivating mutations in the ABCC8 gene in neonatal diabetes mellitus.Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsA new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitorsvon Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulationPer-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretionSmall-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouseRegulation of pancreatic endocrine cell differentiation by sulphated proteoglycansSystematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetesChild health, developmental plasticity, and epigenetic programmingMolecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.Development of the pancreas in medaka.HIF1α and pancreatic β-cell development.Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme.Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathwayDisruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.Alternative sources of beta cells for cell therapy of diabetes.Human pancreas endocrine cell populations and activating ABCC8 mutations.Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation.Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in ratsEfficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors.Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.Fetal pancreas transplants are dependent on prolactin for their development and prevent type 1 diabetes in syngeneic but not allogeneic mice.Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitorsNeonatal hyperglycaemia and abnormal development of the pancreas.Control of pancreatic development by intercellular signals.Mouse muscle as an ectopic permissive site for human pancreatic development.Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas.The hexosamine biosynthesis pathway is essential for pancreatic beta cell development.Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.Expression of functional nerve growth factor receptors in pancreatic beta-cell lines and fetal rat islets in primary culture.Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu.Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.A human beta cell line with drug inducible excision of immortalizing transgenes.
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description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Raphael Scharfmann
@ast
Raphael Scharfmann
@en
Raphael Scharfmann
@es
Raphael Scharfmann
@nl
Raphael Scharfmann
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type
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Raphael Scharfmann
@ast
Raphael Scharfmann
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Raphael Scharfmann
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Raphael Scharfmann
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Raphael Scharfmann
@sl
prefLabel
Raphael Scharfmann
@ast
Raphael Scharfmann
@en
Raphael Scharfmann
@es
Raphael Scharfmann
@nl
Raphael Scharfmann
@sl
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P166
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0000-0001-7619-337X