The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
about
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingCbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiationStructural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsIdentification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1Identification and functional characterization of an Src homology domain 3 domain-binding site on CblCbl-ArgBP2 complex mediates ubiquitination and degradation of c-AblMembrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformationNegative regulation of Lck by Cbl ubiquitin ligasec-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPasesRuk is ubiquitinated but not degraded by the proteasomeBeta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activationIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.Regulation of the Src family kinase Lck by Hsp90 and ubiquitinationThe Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in micec-Cbl-mediated regulation of LAT-nucleated signaling complexesDistinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assemblyPleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell lineThe linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.Roles of E3 ubiquitin ligases in cell adhesion and migration.Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.Myristoylation and membrane binding regulate c-Src stability and kinase activityCbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases.Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptorsCdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1AConstitutive endocytosis and degradation of the pre-T cell receptor.Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Vascular smooth muscle cell motility is mediated by a physical and functional interaction of Ca2+/calmodulin-dependent protein kinase IIδ2 and Fyn.Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunityThe c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.Cbl family proteins: balancing FcεRI-mediated mast cell and basophil activation.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.
P2860
Q24291874-469A5FBD-AA61-48EB-B137-E3D56DD26E70Q24296414-861D4DE9-B48F-4A2B-8284-133DB63F2738Q24297076-C4825144-4CD5-41D0-AF04-8A8914EFC8BDQ24298086-B9D7E3C1-A263-443A-A9DF-85EA935F3EAFQ24313251-2113A7D5-B282-458F-AA4B-E50CCEB0A2CDQ24535526-2DAAEB0A-A2F8-47A5-B259-1A16007D6394Q28207560-01A32D39-1C5C-4F9C-9927-FD280CC69936Q28208259-8ED991AE-C109-42CD-9D61-03A3178080F6Q28213787-7E2364E8-8805-454A-99A7-08AB575312CCQ28215630-99AE1B99-7B1C-4E11-B4E5-379B5D6C2AF2Q28359741-57AC8CC3-3541-44B8-8CA0-EF94F439AC64Q28366332-1BD358C7-0B57-4EBA-ADE5-3E1BEF0760BAQ28577409-D6B92837-8999-4A68-96D1-3ECFD8A8E0FEQ30009956-C66FD8A0-C59C-4D53-84BF-14F108CD9965Q30164012-EA9DCAB6-BF87-4A6C-A970-24E2771C0D14Q30167736-51E55EA0-8AB6-46F1-A92D-C0E88AD11B35Q30436404-E1B4264E-E049-4D6F-9988-A8DCBD357FC8Q30480971-3CB8F2A2-DBFB-4A56-9843-CFB207BE7E26Q33292370-09313471-8AAC-4DFF-A216-3B17DD688BF0Q33321224-662B4919-60B5-4981-8384-7A4E8EA14A33Q33606123-06EE67EF-8EBE-474D-9E99-FC165665BB29Q33661530-9F14F97A-56ED-4C7A-8C07-AFEF33BAD639Q33781079-E4A66E38-9A17-43BD-9EE4-934FD77A6234Q33948376-DC56842C-F52B-442A-94AE-99B58F97B53BQ34119774-DD2BB003-28D9-42D2-8BA8-43EB3E7B8B10Q34205572-B207E2B2-343D-432B-8793-960C1F304AA4Q34405560-A16B9954-257F-4DA5-A9A5-37309002E639Q34450011-A2BC6C18-A81C-4F9F-94A4-78280114827CQ34806104-764F8C1B-33D7-4F6E-8C06-F91905C3F4D7Q35199261-19EB663F-D286-4960-9BEF-AFEDC2C9D156Q35604557-631B9E57-5957-4178-9B02-61B1D5EB25D0Q36369757-3CF11091-CD37-4AAA-84A2-F1BA9B24677CQ36508969-B813F197-E5CD-4BA3-BB83-692309DC5139Q37226190-05040F40-F20D-431D-8FFA-201370AC6D43Q37283549-EE0BEA99-2F18-4CFA-A5C3-0971C5FFF9CCQ37400412-3C124A20-7F5B-40DD-B76B-246075FDD24BQ37460098-BD0FF703-22CB-4967-B295-C16AD2BE54C4Q37859217-55230D85-2EE9-48B9-BC67-5310464FA599Q38074797-BF8169FF-6B77-4FD4-8AF9-0D5B42DFA66FQ38363901-A7211676-C104-488F-9930-31A0AEF9F069
P2860
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The Cbl proto-oncogene product ...... by enhancing its degradation.
@ast
The Cbl proto-oncogene product ...... by enhancing its degradation.
@en
type
label
The Cbl proto-oncogene product ...... by enhancing its degradation.
@ast
The Cbl proto-oncogene product ...... by enhancing its degradation.
@en
prefLabel
The Cbl proto-oncogene product ...... by enhancing its degradation.
@ast
The Cbl proto-oncogene product ...... by enhancing its degradation.
@en
P2093
P2860
P1476
The Cbl proto-oncogene product ...... by enhancing its degradation.
@en
P2093
C E Andoniou
D D Bowtell
M L Lupher
R M Scaife
W Y Langdon
P2860
P304
P356
10.1128/MCB.20.3.851-867.2000
P407
P577
2000-02-01T00:00:00Z