Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity.
about
Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsDementia of the eye: the role of amyloid beta in retinal degenerationDisrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsA flash in the pan: dissecting dynamic amyloid intermediates using fluorescenceMolecular basis of -amyloid oligomer recognition with a conformational antibody fragmentCrystal Structure of a Human Prion Protein Fragment Reveals a Motif for Oligomer FormationX-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ 17–36A Fibril-Like Assembly of Oligomers of a Peptide Derived from β-AmyloidInteraction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formationElectrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formationAn Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity.Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.Stepwise organization of the β-structure identifies key regions essential for the propagation and cytotoxicity of insulin amyloid fibrils.Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomersComparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin.Ortho-methylated 3-hydroxypyridines hinder hen egg-white lysozyme fibrillogenesis.Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living CellsThe conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length.A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure.PASTA 2.0: an improved server for protein aggregation prediction.Transthyretin-derived peptides as β-amyloid inhibitors.Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Interplay of sequence, topology and termini charge in determining the stability of the aggregates of GNNQQNY mutants: a molecular dynamics study.Small molecule screening in context: lipid-catalyzed amyloid formation.Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles.Effect of single point mutations in a form of systemic amyloidosis.Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoidA Kinetic Model for Cell Damage Caused by Oligomer Formation.Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.Corruption and spread of pathogenic proteins in neurodegenerative diseases.Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial AmyloidStudy of structural stability and damaging effect on membrane for four Aβ42 dimers.Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal systemStructures of oligomers of a peptide from β-amyloid.Linking in domain-swapped protein dimers
P2860
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P2860
Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@ast
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@en
type
label
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@ast
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@en
prefLabel
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@ast
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@en
P1476
Oligomeric intermediates in am ...... on and mechanisms of toxicity.
@en
P2093
Marcus Fändrich
P304
P356
10.1016/J.JMB.2012.01.006
P407
P577
2012-01-12T00:00:00Z