Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

Item
http://www.wikidata.org/entity/Q30371474
Antibody humanization by structure-based computational protein design.Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo.Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function.Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.Immunogenicity of therapeutic recombinant immunotoxins.OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design.Design and engineering of deimmunized biotherapeutics.Immunity to CRISPR Cas9 and Cas12a therapeutics.Computationally-driven identification of antibody epitopes.GradDock: Rapid Simulation and Tailored Ranking Functions for Peptide-MHC Class I Docking.Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity.Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Demmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins.DisruPPI: structure-based computational redesign algorithm for protein binding disruption.
P2860

Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

Item
http://www.wikidata.org/entity/Q30371474
description
2015 nî lūn-bûn
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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Protein deimmunization via str ...... etion at high mutational loads
@ast
Protein deimmunization via str ...... etion at high mutational loads
@en
type
label
Protein deimmunization via str ...... etion at high mutational loads
@ast
Protein deimmunization via str ...... etion at high mutational loads
@en
prefLabel
Protein deimmunization via str ...... etion at high mutational loads
@ast
Protein deimmunization via str ...... etion at high mutational loads
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Protein deimmunization via str ...... etion at high mutational loads
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P932