Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
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Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during InflammationGenetics of rheumatoid arthritis contributes to biology and drug discoverySeasonal Variations of Complete Blood Count and Inflammatory Biomarkers in the US Population - Analysis of NHANES DataNeutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma.The impact of rare and low-frequency genetic variants in common diseaseGenetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy.Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target.A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammationA new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart diseaseLipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.Widespread seasonal gene expression reveals annual differences in human immunity and physiologySeeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10.Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6.Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins.Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysisIn-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment.Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Identification of STOML2 as a putative novel asthma risk gene associated with IL6R.Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population.Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation.The rs2228145 polymorphism in the interleukin-6 receptor and its association with long-term prognosis after myocardial infarction in a pilot study.The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome.Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1The use of monoclonal antibodies to treat Castleman's disease.IL-6 biology: implications for clinical targeting in rheumatic disease.Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating MicrovesiclesImmune-mediated mechanisms of atherosclerosis and implications for the clinic.Interleukin-6 "Trans-Signaling" and Ischemic Vascular Disease: The Important Role of Soluble gp130.The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation.A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register.
P2860
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P2860
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@ast
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@en
type
label
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@ast
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@en
prefLabel
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@ast
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@en
P2093
P2860
P50
P1433
P1476
Functional IL6R 358Ala allele ...... diverse inflammatory diseases
@en
P2093
Charlotte Boreham
Daniel B Rainbow
Daniel F Freitag
Joanna M M Howson
John Danesh
Marcin L Pekalski
Pamela Clarke
Ricardo C Ferreira
Richard M Coulson
Stephen Kaptoge
P2860
P304
P356
10.1371/JOURNAL.PGEN.1003444
P577
2013-04-04T00:00:00Z