Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
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Detailed mechanistic investigation into the S-nitrosation of cysteaminePhosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionParkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell deathATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkinProgrammed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's diseaseDopamine covalently modifies and functionally inactivates parkinBroad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingS-nitrosothiols signal hypoxia-mimetic vascular pathologyUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentRedox control of protein degradationRBR E3 ubiquitin ligases: new structures, new insights, new questionsMechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylationMolecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionPathologic and therapeutic implications for the cell biology of parkinRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationStructure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's diseaseStructure of parkin reveals mechanisms for ubiquitin ligase activationS-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family ProteinC-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.14-3-3eta is a novel regulator of parkin ubiquitin ligase.S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseasealpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson diseaseThe branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase--implications in Alzheimer's diseaseNO signaling and S-nitrosylation regulate PTEN inhibition in neurodegenerationGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseiSNO-PseAAC: predict cysteine S-nitrosylation sites in proteins by incorporating position specific amino acid propensity into pseudo amino acid compositionTSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality controlThe S-nitrosylation status of PCNA localized in cytosol impacts the apoptotic pathway in a Parkinson's disease paradigmiSNO-AAPair: incorporating amino acid pairwise coupling into PseAAC for predicting cysteine S-nitrosylation sites in proteinsThe effects of oxidative stress on parkin and other E3 ligases.ROSics: chemistry and proteomics of cysteine modifications in redox biology.Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseasesEndogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cellsS-nitrosothiol depletion in amyotrophic lateral sclerosis.Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.Role of the ubiquitin proteasome system in Parkinson's disease.Protein post-translational modifications: In silico prediction tools and molecular modeling.Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress.
P2860
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P2860
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@ast
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@en
type
label
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@ast
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@en
prefLabel
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@ast
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@en
P2093
P2860
P356
P1476
Nitrosative stress linked to s ...... E3 ubiquitin ligase activity.
@en
P2093
Benjamin Gaston
Dongdong Yao
Edward M Rockenstein
Lisa A Palmer
Stuart A Lipton
Takashi Uehara
Tomohiro Nakamura
Yuliang Ma
Zhong-Qing Shi
P2860
P304
10810-10814
P356
10.1073/PNAS.0404161101
P407
P577
2004-07-13T00:00:00Z