Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization - sprookjes - yvandenbroek - TriplyDB

Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization

Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization

http://www.wikidata.org/entity/Q30475334

about

Emerging preclinical pharmacological targets for Parkinson's disease Striatal cholinergic interneuron regulation and circuit effects Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice Nicotine from cigarette smoking and diet and Parkinson disease: a review.Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson's disease.Role for the nicotinic cholinergic system in movement disorders; therapeutic implications.Nicotine as a potential neuroprotective agent for Parkinson's disease.Developmental nicotine exposure alters neurotransmission and excitability in hypoglossal motoneurons Focus on α4β2* and α6β2* nAChRs for Parkinson's Disease Therapeutics.Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian rats.Nicotine reduces L-DOPA-induced dyskinesias by acting at beta2* nicotinic receptors.α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats.Anatomy of Graft-induced Dyskinesias: Circuit Remodeling in the Parkinsonian Striatum Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage.Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats.Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia Nicotinic receptor agonists reduce L-DOPA-induced dyskinesias in a monkey model of Parkinson's disease.Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson's disease Striatal cholinergic cell ablation attenuates L-DOPA induced dyskinesia in Parkinsonian mice.ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease.Targeting nicotinic receptors for Parkinson's disease therapy.Levodopa-induced dyskinesias in Parkinson's disease: emerging treatments Effect of nicotine on L-dopa-induced dyskinesia in animal models of Parkinson's disease: a systematic review and meta-analysis.Pharmacological strategies for the management of levodopa-induced dyskinesia in patients with Parkinson's disease.Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease.Probing striatal microcircuitry to understand the functional role of cholinergic interneurons.Preclinical Evidence for a Role of the Nicotinic Cholinergic System in Parkinson's Disease.Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation.Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study.The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.PET Molecular Imaging Research of Levodopa-Induced Dyskinesias in Parkinson's Disease.The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release.Multiple CNS nicotinic receptors mediate L-dopa-induced dyskinesias: studies with parkinsonian nicotinic receptor knockout mice.

P2860

Q26764724-92078928-F27E-431E-9D91-1FB2D700F73C Q26863113-5D50D9E9-7648-4B18-BC80-9D285E9238B6 Q28576280-2F0F4C1F-3C6D-4363-BCE2-6C6E4544CA1F Q30450052-6A9707AB-6E8B-4B48-AA14-6604009E65A8 Q33862534-5EAFC3CA-B9EA-4F4D-807F-88E46FB3E268 Q33917311-339C6BAF-F0A8-4E28-8F8B-24075F0DC74B Q34112026-021F2CBC-BA00-4109-AB24-876A09A30BEC Q34281003-3EF722B5-B789-4159-BAD3-0AE9E8D5CB6E Q34502617-F4B7B9D3-E31B-4072-8813-602F30A8140F Q34793270-50C71C3A-0A9F-49DD-8D46-C3E3CCA4C0F6 Q35097046-DB0D335F-22FD-4D98-8320-4C32C4D41ECE Q35188119-6E3C9C6A-5B7E-47C9-8649-1DEB4A218B36 Q35264378-0D62595F-E379-40C7-9377-FA83CD55E7FF Q35533526-7572BB17-EA61-4033-BEDA-CEC238724557 Q35690145-EABBBE5C-C224-4D26-A5F4-683A67D5BFEE Q35776860-E48F7C14-2C12-495C-8C4B-39BCAD4FC893 Q36034592-463CA917-00AB-4FD3-B85B-1B6EAADD4A8C Q36079677-2EB17E01-8837-40E9-94A9-34892D07F6AD Q36469995-C94FB6C2-DE4E-4385-B4F1-6D3D0A7CB41B Q36880148-7DFFF918-4CF2-4FA7-858B-FAF7AA9C318B Q36936920-6828C6F1-05F8-4243-9A80-77F4248F6D07 Q36936930-90552B48-3E40-4BEE-A5A7-F045A80B8B42 Q37154555-BC25512E-B64E-4ADD-A3EA-7685287ACB62 Q37193201-C4AD3769-8954-4835-B5EF-A921B84E2599 Q37209730-3F76EF2F-FB29-44AF-B316-3F2BF1AA481D Q37597274-F6CFFD1D-7E59-45BE-80DE-7C7533856D53 Q37708588-BF4F8BE6-033B-4FBF-92CD-290FA1F91551 Q37916643-56BE6E9B-B7D2-444A-85E1-F745D416B303 Q38156760-0BA5F4A4-7D5E-4CAE-9478-3AA17FD76875 Q38186596-B446D048-D096-4ADD-94A7-213BBAC79718 Q38262418-F9CE50B9-7738-474D-8FAF-DC48A29AD2AD Q38532889-4F200C38-1FD3-4795-8479-A63A4A352EE9 Q38557880-0EA5E573-23FC-4A62-A4B1-EFD7CBDF5F64 Q38629277-E6F3667E-4475-47B0-8681-EF155868D7F9 Q39250067-5EF72E4E-9E46-4850-9183-367D36E48A4C Q41510167-66EAD7E8-E5EC-4547-87D2-95DEE9B01ABF Q42094999-70BAC7DC-E836-4045-B9A3-6FB2C2387318 Q42369736-2D773D35-09E7-4181-B017-C6C3533E7148 Q42640556-C8B09907-F8E0-4C0E-81D3-475BAD6C04BB Q42676936-34873299-8B6D-4ACC-8013-A6C0448D1C0D

P2860

Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization

http://www.wikidata.org/entity/Q30475334

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Nicotinic receptor-mediated re ...... may occur via desensitization

@ast

Nicotinic receptor-mediated re ...... may occur via desensitization

@en

type

label

Nicotinic receptor-mediated re ...... may occur via desensitization

@ast

Nicotinic receptor-mediated re ...... may occur via desensitization

@en

prefLabel

Nicotinic receptor-mediated re ...... may occur via desensitization

@ast

Nicotinic receptor-mediated re ...... may occur via desensitization

@en

P1433

Q30475334-F2C7EE47-A027-4C44-8435-6E7E208EE1E3

P1476

Q30475334-B7C73008-3064-4A95-A0C7-9B0E6E3C2BE6

P2093

Q30475334-54560957-C55D-4C0A-97D6-F6D7289313E1

Q30475334-5DBD03BC-6108-43D9-9CB4-C236F8C89E92

Q30475334-72B3E673-03DD-42C4-BA2C-52F88DDEA15D

Q30475334-84F69F3A-3F28-4D01-8E8A-F2AE81037664

P2860

Q30475334-01093DA5-4658-4C04-9DF5-4AFE73896E5C

Q30475334-0214AC32-1188-461D-BF14-BB30AC284595

Q30475334-0E11908A-9960-4991-B451-6134D31555C1

Q30475334-11122BAE-BB2F-4914-BC34-F9780BE8C21F

Q30475334-212BDA55-EF1B-470F-8E72-CEDF53B23430

Q30475334-24CE9CBD-1D11-4EB8-985D-49BE43DFB57A

Q30475334-2744EB15-DAAB-4F0B-891A-DE1DD29951B6

Q30475334-277B9DB8-E4DF-434F-A608-D937835124B7

Q30475334-350A778E-6649-4E96-A64C-3AB65B8A9928

Q30475334-47E98273-92D1-4264-BE83-E39635D46403

P304

Q30475334-4D63321F-9186-47BC-AE37-047FD7D86195

P31

Q30475334-063C636B-32FD-400D-9A0B-B1D01A72131F

P356

Q30475334-B754FD70-B6AA-4618-A387-2C06A8B9C64D

P407

Q30475334-2E7A4C49-B375-4394-BEC2-FB2053348C96

P433

Q30475334-A22E7460-4A73-425E-BDDF-4680265D0939

P478

Q30475334-1511C759-63B3-41F7-AC1B-58A5BB096105

P577

Q30475334-151E43DF-8AD9-495C-B70B-6310911FD1F7

P5875

Q30475334-186D87F7-07DC-4140-807F-6E2D26E248C2

P698

Q30475334-7DD4CB90-0B43-4ED0-9243-2A089CB5FF5C

P921

Q30475334-770BD58E-426E-49AC-B7CD-8FACBC5C30AE

P932

Q30475334-EB49B610-CC70-4C4C-A354-1FB1F9B8A001

P356

JPET.109.162396

P1433

Journal of Pharmacology and Experimental Therapeutics

P1476

Nicotinic receptor-mediated re ...... may occur via desensitization

@en

P2093

Carla Campos

http://www.w3.org/2001/XMLSchema#string

J Michael McIntosh

http://www.w3.org/2001/XMLSchema#string

Maryka Quik

http://www.w3.org/2001/XMLSchema#string

Tanuja Bordia

http://www.w3.org/2001/XMLSchema#string

P2860

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors

Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.

Mammalian nicotinic acetylcholine receptors: from structure to function

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices

(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner.

Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure.

TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects.

Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys.

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

P304

929-938

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1124/JPET.109.162396

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

333

http://www.w3.org/2001/XMLSchema#string

P577

2010-03-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

41721925

http://www.w3.org/2001/XMLSchema#string

P698

20200117

http://www.w3.org/2001/XMLSchema#string

P921

P932

2879940

http://www.w3.org/2001/XMLSchema#string