Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. - sprookjes - yvandenbroek - TriplyDB

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.

http://www.wikidata.org/entity/Q30476018

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IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist use.Human Mena associates with Rac1 small GTPase in glioblastoma cell lines Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase Mechanism of filopodia initiation by reorganization of a dendritic network.Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.WAVE binds Ena/VASP for enhanced Arp2/3 complex-based actin assembly.Vasodilator-stimulated phosphoprotein (VASP) induces actin assembly in dendritic spines to promote their development and potentiate synaptic strength.Ena/VASP proteins have an anti-capping independent function in filopodia formation.Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts.A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.The actin regulators Enabled and Diaphanous direct distinct protrusive behaviors in different tissues during Drosophila development.5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway.Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function.Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells.VASP is a processive actin polymerase that requires monomeric actin for barbed end association.VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity.Mammalian enabled (Mena) is a critical regulator of cardiac function.Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer Do filopodia enable the growth cone to find its way?Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway.Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM How VASP enhances actin-based motility Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking Mena binds α5 integrin directly and modulates α5β1 function.Selectivity in subunit composition of Ena/VASP tetramers.Expression and Distribution Characteristics of Human Ortholog of Mammalian Enabled (hMena) in Glioma Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery

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Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.

http://www.wikidata.org/entity/Q30476018

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年论文

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Critical roles of phosphorylat ...... unction during cell migration.

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Critical roles of phosphorylat ...... unction during cell migration.

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Critical roles of phosphorylat ...... unction during cell migration.

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Critical roles of phosphorylat ...... unction during cell migration.

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Critical roles of phosphorylat ...... unction during cell migration.

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MBC.E01-10-0102

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Molecular Biology of the Cell

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Critical roles of phosphorylat ...... unction during cell migration.

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Adam V Kwiatkowski

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Douglas A Rubinson

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Frank B Gertler

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Gretchen A Baltus

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James E Bear

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Joseph J Loureiro

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P2860

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts

The actin binding site of thymosin beta 4 mapped by mutational analysis

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins

Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility

Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function

Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed

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2533-2546

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10.1091/MBC.E01-10-0102

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7

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13

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2002-07-01T00:00:00Z

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12134088

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phosphorylation

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117332

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