Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.
about
The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutationMouse models of polyglutamine diseases: review and data table. Part IPathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophyThe polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Myocyte androgen receptors increase metabolic rate and improve body composition by reducing fat mass.Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophyAndrogen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patientsMicroarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophyAntiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development.Muscle matters in Kennedy's disease.Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophyAndrogen receptor and Kennedy disease/spinal bulbar muscular atrophyMacroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.Myocytic androgen receptor controls the strength but not the mass of limb muscles.Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy.Spinal and Bulbar Muscular Atrophy.Overexpression of androgen receptors in target musculature confers androgen sensitivity to motoneuron dendrites.Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophyManaging anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs.Transcriptional profile of muscle following acute induction of symptoms in a mouse model of Kennedy's disease/spinobulbar muscular atrophy.Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy.Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action.Androgen-dependent loss of muscle BDNF mRNA in two mouse models of SBMA.Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophyThe anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.Current status of treatment of spinal and bulbar muscular atrophy.Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.Androgen receptors, sex behavior, and aggression.Removal of reproductive suppression reveals latent sex differences in brain steroid hormone receptors in naked mole-rats, Heterocephalus glaberTranscriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments.Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells
P2860
Q24652658-6477668D-CCF8-4922-8597-CFBD9485C7C0Q26853025-158BF735-E3AD-436A-BC36-C17D50E4B3D0Q27007098-29F353E8-0EF4-4AA2-82A2-EC44935EFDC8Q27342782-CF8C8FAA-8CE4-450E-9918-5ED44E92D222Q30370542-4357176B-2817-4B12-8E41-741E722CAC9AQ30405294-7CFA66F8-A7A1-468A-9687-131BA46E4FB5Q30423500-790FB817-59CF-4FF1-B0DE-0C7DDC580E7EQ30495489-D2D00A91-4102-4BF9-833C-D4DFF6686F18Q30498024-8FF7B9E8-0AE1-4B7B-931B-A41135FF2CCAQ33589145-E4C412A2-B127-4AC6-A525-825F6DE511C4Q33614611-FC4CBEC4-F33F-4D40-9885-E16002271486Q33707651-944C9B9C-F6FB-44E1-B4CC-11F587D300CAQ33765455-DC786C3C-3252-4441-8BCE-3218675582DCQ33830458-E20C01F5-4D4A-4BCC-BB2B-137D2505582DQ33860974-F1BC0A4F-8F70-43C4-84E9-DDB702E5B9ADQ33894661-F2A2E00E-DCC6-45F3-8A20-7EDA2A9638D1Q33904073-C6D42D94-FA94-4F25-9B4D-CDC49AED32D9Q34055364-1EE61F8B-2A83-4E62-8E7A-7B56D2BF6BFAQ34069603-A11FEA22-3A66-403B-90DD-33CD1AC3C068Q34407293-F73A65D0-71C0-4071-967F-2E7FDDF1F5D9Q34499899-25997DD7-1DFD-45EA-B864-C11F1D9501F3Q34566587-7F8D368E-7C47-4BC0-879B-D1D0E2E7F349Q34637225-96F099DC-FCAD-4821-879A-A9C77B184FA5Q34642189-F17092E2-B4CE-4DAD-92B2-29CD7FFDE0FDQ34669046-940CCB59-5271-4C16-A64B-2441BD3B5739Q35124720-7C817E95-3857-4B5F-8DF6-077126FC9693Q35273916-8B34FF2D-E9E5-4776-8FA0-C27C4D23BB0EQ35389582-CB041B00-8E8E-40F2-AA7B-2281B08F9162Q35655716-25219758-BEAE-443F-9160-32C05292BFA6Q35665068-1B2B96E1-AEF1-4361-9315-C136753C1F7BQ35737086-9CED3759-CC07-4F72-A5CD-D3FB18E7FFEAQ35837254-EFE97BC8-0972-4DD4-9E10-2877694C8BA8Q36037644-3DF388DE-4369-4954-BE1F-9482EE39FAAAQ36081124-EC79DE78-302D-4B14-BCF1-D3C21F874C27Q36189002-7CD1B0F9-7608-4E3A-A93D-96F65996C370Q36326556-75469F39-D7EA-4850-BE0B-E3166F02F1D2Q36364204-2AD92EA2-B8E6-46E6-81AD-0C21F933A896Q36670771-2D0BDF35-4C80-4AD5-AA9A-770625995558Q36805205-DC64680A-4A4B-4388-9A38-D20AA7EB931BQ36809544-E033D6C0-D5D0-4364-9FE4-6AAAF342A6BB
P2860
Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Overexpression of wild-type an ...... tulates polyglutamine disease.
@ast
Overexpression of wild-type an ...... tulates polyglutamine disease.
@en
type
label
Overexpression of wild-type an ...... tulates polyglutamine disease.
@ast
Overexpression of wild-type an ...... tulates polyglutamine disease.
@en
prefLabel
Overexpression of wild-type an ...... tulates polyglutamine disease.
@ast
Overexpression of wild-type an ...... tulates polyglutamine disease.
@en
P2093
P2860
P356
P1476
Overexpression of wild-type an ...... itulates polyglutamine disease
@en
P2093
Andrew P Lieberman
Bryn Eagleson
Cynthia L Jordan
Douglas Ashley Monks
Pengcheng Rao
Zhigang Yu
P2860
P304
18259-18264
P356
10.1073/PNAS.0705501104
P407
P577
2007-11-02T00:00:00Z