Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. - sprookjes - yvandenbroek - TriplyDB

Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.

Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.

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The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation Mouse models of polyglutamine diseases: review and data table. Part I Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Myocyte androgen receptors increase metabolic rate and improve body composition by reducing fat mass.Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy Androgen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development.Muscle matters in Kennedy's disease.Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.Myocytic androgen receptor controls the strength but not the mass of limb muscles.Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy.Spinal and Bulbar Muscular Atrophy.Overexpression of androgen receptors in target musculature confers androgen sensitivity to motoneuron dendrites.Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs.Transcriptional profile of muscle following acute induction of symptoms in a mouse model of Kennedy's disease/spinobulbar muscular atrophy.Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy.Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action.Androgen-dependent loss of muscle BDNF mRNA in two mouse models of SBMA.Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.Current status of treatment of spinal and bulbar muscular atrophy.Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.Androgen receptors, sex behavior, and aggression.Removal of reproductive suppression reveals latent sex differences in brain steroid hormone receptors in naked mole-rats, Heterocephalus glaber Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments.Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells

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Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.

http://www.wikidata.org/entity/Q30480713

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2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007年の論文

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Overexpression of wild-type an ...... tulates polyglutamine disease.

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Proceedings of the National Academy of Sciences of the United States of America

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Overexpression of wild-type an ...... itulates polyglutamine disease

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Andrew P Lieberman

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Bryn Eagleson

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Cynthia L Jordan

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Douglas Ashley Monks

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Kaiguo Mo

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Pengcheng Rao

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Zhigang Yu

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P2860

Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model

alpha-Synuclein locus triplication causes Parkinson's disease

The biology of VEGF and its receptors

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases

A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data

Glutamine repeats and neurodegeneration.

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.

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46

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104

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Jamie A Johansen

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2007-11-02T00:00:00Z

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5862738

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