Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats - sprookjes - yvandenbroek - TriplyDB

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

http://www.wikidata.org/entity/Q30575773

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Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation From animal models to human disease: a genetic approach for personalized medicine in ALS Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Neuroinflammation in motor neuron disease Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Novel molecular biomarkers at the blood-brain barrier in ALS Fluoxetine pretreatment promotes neuronal survival and maturation after auditory fear conditioning in the rat amygdala Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues.Profiling the genes affected by pathogenic TDP-43 in astrocytes Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle.Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Astroglial cradle in the life of the synapse.Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.Rodent Models of Amyotrophic Lateral Sclerosis Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms.Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS Pathogenic Ubqln2 gains toxic properties to induce neuron death.Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.Amyotrophic lateral sclerosis: Problems and prospects.Glial cells in amyotrophic lateral sclerosis Astrocytes in neurodegenerative disease.TDP-43-The key to understanding amyotrophic lateral sclerosis.The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers.Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.Are astrocytes executive cells within the central nervous system?The non-cell-autonomous component of ALS: new in vitro models and future challenges.Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.Increased Ubqln2 expression causes neuron death in transgenic rats The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.Temporal Expression of Mutant TDP-43 Correlates with Early Amyotrophic Lateral Sclerosis Phenotype and Motor Weakness.Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.

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Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

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2013 nî lūn-bûn

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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The EMBO Journal

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Expression of ALS-linked TDP-4 ...... ous motor neuron death in rats

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Bo Huang

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Cao Huang

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Fang Li

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Fangfang Bi

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Hongxia Zhou

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Jianbin Tong

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Qinxue Wu

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Xionghao Liu

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Xu-Gang Xia

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P2860

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans

FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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1917-1926

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10.1038/EMBOJ.2013.122

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amyotrophic lateral sclerosis

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3981181

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